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品种反应性 主要应用 宿主 格式 抗体类型 Mk, H, M IH(P) Rb Purified Polyclonal Antibody 描述 产品目录编号 AB5407 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Opsin Antibody, blue 背景信息 The full range of color discrimination in humans is based on the presence and function of three cone photoreceptor mechanisms. Each cone type possesses a photo-sensitive pigment-protein complex consisting of 11-cis retinal and a unique opsin protein, which gives sensitivity in the short (S cone, peak sensitivity about 420nm), middle (M cone, peak sensitivity about 530nm with polymorphism; Winderckx et al., 1993; Neitz & Neitz, 1998), and long (L cone, peak sensitivity about 560nm with polymorphism; Neitz & Jacobs, 1990) wavelengths of the light spectrum. All three opsins are transmembrane proteins with seven membrane-spanning regions. Genes for the three types of cone opsins and the rod photoreceptor rhodopsin gene seem to be homologous with varying amounts of conservation. Strongest conservation is between the middle (green) and long (red) wavelength sensitive pigments on the X chromosome, suggesting a relatively recent duplication/divergence event (Nathans, 1989; Nathans et al., 1992). The S cone (blue) opsin is located on chromosome 7 and seems to have stronger conservation with rhodopsin. Cone photoreceptor distribution in humans is dominated by the M and L cone pigments. 产品信息 格式 Purified 控制 - Retina
演示 Purified immunoglobulinin PBS {0.02M phosphate, 0.25M NaCl, pH 7.6} with 0.1% sodium azide as a preservative 应用 应用 This Anti-Opsin Antibody, blue is validated for use in IH(P) for the detection of Opsin. 主要应用 - Immunohistochemistry (Paraffin)
应用说明 Immunohistochemistry: 1:200-1:300 on formalin-fixed, paraffin-embedded mouse retina tissue. Antigen retrieval method recommend is HIER with steam heat; other fixation and retrieval methods are untested.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Recombinant human blue opsin. 表位 blue 宿主 Rabbit 特异性 Recognizes Opsin, blue. 品种反应性 MonkeyHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001708.1
基因符号 - BCP
- OPN1SW
- CBT
- BOP
纯化方法 Protein A purfied UniProt编号 - P03999
UniProt汇总 FUNCTION: SwissProt: P03999 # Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
SIZE: 348 amino acids; 39135 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: The three color pigments are found in the cone photoreceptor cells.
PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
DISEASE:SwissProt: P03999 # Defects in OPN1SW are the cause of tritan color blindness (tritanopia) [MIM:190900].SIMILARITY:SwissProt: P03999 ## Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at 2–8°C from date of shipment. 包装信息 数量 100 µg
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