merck millipore,默克密理愽
  • merck millipore,默克密理博,04-571,Anti-Caspase 2 Antibody, rabbit monoclonal

  • merck millipore,默克密理博,04-571,Anti-Caspase 2 Antibody, rabbit monoclonal

    产品名称：Anti-Caspase 2 Antibody, rabbit monoclonal
    产品型号：04-571
    Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Caspase 2 using this Anti-Caspase 2 Antibody  More>>

    merck millipore,默克密理博,04-571,Anti-Caspase 2 Antibody, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-571,Anti-Caspase 2 Antibody, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, FCRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-571
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Caspase 2 Antibody, rabbit monoclonal
    背景信息 Caspase-2 (Nedd2/ICH-1) is part of a family of aspartate-specific cysteine proteases that participate in programmed cell death, or apoptosis. Caspase-2 is localized to the nucleus, and has been shown to play roles in both positive and negative regulation of apoptosis (1). Upon apoptotic stimulation, pro-caspase-9 is cleaved in a series of steps to produce an 18-kDa large subunit and a 12-kDa small fragment (2). Caspase-2 can be a nuclear initiator caspase, as it has been shown to precede the processing and activation of caspase-8, -9, and -3 (3). Caspase-2 might also act as an effector caspase; in apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of caspase-9 and caspase-3 activation (4).
    产品信息
    格式 Purified
    演示 Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
    应用
    应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Caspase 2 using this Anti-Caspase 2 Antibody validated for use in FC & WB.
    主要应用
    • Western Blotting
    • Flow Cytometry
    应用说明 WB: 1:500
    Flow Cytometry: 1:10
    生物信息
    免疫原品种 A synthetic peptide corresponding to N-terminus of human Caspase-2 p15 subunit. The antibody should recognize both pro-form (~50kDa) and p15 cleaved-form of Caspase-2.
    克隆 Y61
    宿主 Rabbit
    特异性 Recognizes Human, Mouse Caspase-2.
    品种反应性 MouseHuman
    Species Reactivity Note Human, Mouse (positive control: Jurkat cell lysate)
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_032983.2
    • NM_032982.2
    Entrez基因汇总 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
    基因符号
    • CASP-2
    • CASP2
    • NEDD2
    • ICH1
    • ICH-1L/1S
    • ICH-1L
    • NEDD-2
    UniProt编号
    • P42575
    UniProt汇总 FUNCTION: SwissProt: P42575 # Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
    SIZE: 452 amino acids; 50685 Da
    SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD.
    TISSUE SPECIFICITY: Expressed in larger amounts in the embryonic lung, liver and kidney than in the heart and brain. In the adults higher level expression is seen in the placenta, lung, kidney, pancreas than in the heart, brain, liver and skeletal muscle.
    PTM: The mature protease can process its own propeptide, but not that of other caspases.
    SIMILARITY: SwissProt: P42575 ## Belongs to the peptidase C14 family. & Contains 1 CARD domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -20 °C. Stable for 12 months from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-571,Anti-Caspase 2 Antibody, rabbit monoclonal

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