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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC331 描述 Anti-PALB2 Antibody Alternate Names - FANCN
- Partner and localizer of BRCA2
背景信息 Partner and localizer of BRCA2 (PALB2) is the critical protein required for the homologous recombination repair at DNA breaks. It serves as a scaffold protein in the formation of the BRAC1-PALB2-BRAC2 complex which is essential for homologous recombination. Essentially a partner of BRAC2, PALB2 localizes BRAC2 and stabilizes it. PALB2 enables BRAC2 to perform its recombinational repair and checkpoint functions in addition to its DNA repair functions. Also by binding BRAC2, PALB2 is thought to help BRCA2 avoid degradation. PALB2 localizes to the nucleus and has at least four known isoforms. Defects in PALB2 are linked with many forms of breast cancers, pancreatic cancer type 3 (PNCA3), as well as disorders of the bone marrow (Fanconi anemia complementation group, FANCN). These patients suffer numerous cardiac, limb, and skin malformations as well as malignancies. EMD Millipore’s Anti-PALB2 rabbit polyclonal antibody has been tested in western blotting in human SK-N-SH cell lysate samples. 产品信息 格式 Affinity Purified 控制 - SK-N-SH cell lysate
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-PALB2 Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected SPALB2 in human breast cancer tissue.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human PALB2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Polyclonal Antibody 基因符号 - PALB2
纯化方法 Antigen Affinity purified UniProt编号 - Q86YC2
产品使用声明 质量保证 Evaluated by Western Blotting in SK-N-SH cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected PALB2 in 15 µg of SK-N-SH cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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