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merck millipore,默克密理博,IL004,Interleukin-4 Protein, Recombinant human
产品名称：Interleukin-4 Protein, Recombinant human
产品型号：IL004
The recombinant human Interleukin-4 protein (or IL-4 protein) is a potent lymphoid cell growth factor which stimulates the growth & survivability of certain B-cells & T-cells.
merck millipore,默克密理博,IL004,Interleukin-4 Protein, Recombinant human
- 产品介绍
重要规格表
主要应用 品种 纯度 CULT Human Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per mg (1EU/μg) of IL-4. 描述 产品目录编号 IL004 品牌系列 Chemicon®
商名 - Chemicon
描述 Interleukin-4 Protein, Recombinant human 概述 Interleukin-4 (IL-4) is a potent lymphoid cell growth factor which stimulates the growth and survivability of certain B-cells and T-cells, recombinant human IL-4 is a 14.9 kDa protein containing 129 amino acid residues. Alternate Names - IL-4
产品信息 演示 Sterile filtered, lyophilized protein with no additives. 应用 应用 The recombinant human Interleukin-4 protein (or IL-4 protein) is a potent lymphoid cell growth factor which stimulates the growth & survivability of certain B-cells & T-cells. 主要应用 - Cell Culture
应用说明 For most in vitro applications, IL-4 exerts its biological activity in the concentration range of 0.1 to 10 ng/mL. Responding cells are (partial list): B-cells and certain T-cells. 生物信息 纯度 Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per mg (1EU/μg) of IL-4. 品种 Human 特异活性 Human IL-4 is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is <= 0.2 ng/mL, corresponding to a specific activity of >= 5 x 10(E6) units/mg. Entrez基因编号 - NM_172348.1
- NM_000589.2
Entrez基因汇总 The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. 基因符号 - MGC79402
- IL4
- Binetrakin
- Pitrakinra
- BSF1
- BSF-1
- IL-4
UniProt编号 - P05112
UniProt汇总 FUNCTION: SwissProt: P05112 # Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
SIZE: 153 amino acids; 17492 Da
SUBCELLULAR LOCATION: Secreted.
DISEASE: SwissProt: P05112 # Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
SIMILARITY: SwissProt: P05112 ## Belongs to the IL-4/IL-13 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The lyophilized powder, though stable for a few weeks at room temperature, is best stored at -20°C. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 4°C for 1 week or at -20°C for future use. Reconstituted IL-4 should be stored in undiluted aliquots at -20°C for up to six months. 包装信息 数量 20 µg
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下一件merck millipore产品：merck millipore,默克密理博,MSGVN2B50,MultiScreenHTS GV，0.22 µm，不透明，非无菌
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