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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB2915 Replaces 04-434 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Bax Antibody 产品信息 格式 Serum 演示 Liquid antiserum, no preservatives. 应用 应用 This Anti-Bax Antibody is validated for use in WB, IH(P) for the detection of Bax. 主要应用 - Western Blotting
应用说明 Immunohistochemistry (ABC method) on formalin-fixed paraffin-embedded sections (1:600-1:1500)
Immunoblot (1;2500) using ECL detection.
High levels of Bax-alpha are found in areas of the brain, including the cerebrum and cerebellum, as well as the small intestine, stomach, overy, testis, uterus, thymus, and spleen.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 A synthetic peptide corresponding to amino acids 43-61 of the mouse Bax-alpha protein. 宿主 Rabbit 特异性 Recognizes Mouse and Rat Bax-alpha, a 21 kDa protein, as well as a longer 24 kDa. Bax-beta isoform and a 5 kDa Bax-gamma isoform, which are present in much smaller amounts in most tissues. Does not react with other members of the Bcl-2 family, as verified by immunoblot. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_138765.2
- NM_004324.3
- NM_138761.2
- NM_138763.2
- NM_138764.2
Entrez基因汇总 The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. 基因符号 - BAX
UniProt编号 - Q07814
UniProt汇总 FUNCTION: SwissProt: Q07814 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor Bcl-2 or its adenovirus homolog E1B 19k protein.| Q07812 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis.
SIZE: 41 amino acids; 4678 Da
SUBUNIT: Interacts with HN.
SUBCELLULAR LOCATION: Cytoplasm.
DOMAIN: SwissProt: Q07815
DISEASE:SwissProt: Q07812 # Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma.
SIMILARITY: SwissProt: Q07815 ## Belongs to the Bcl-2 family. | Q07814 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.# Belongs to the Bcl-2 family. | P55269 ## Belongs to the Bcl-2 family. | Q07812 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family (By similarity).# Belongs to the Bcl-2 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze-thaw cycles. 包装信息 数量 100 µL
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