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merck millipore,默克密理博,04-142,Anti-IRF4 Antibody, clone 3E4
产品名称：Anti-IRF4 Antibody, clone 3E4
产品型号：04-142
Anti-IRF4 Antibody, clone 3E4 is a highly specific rat monoclonal antibody, that targets IRF4 & has been tested in western blotting, IHC & Flow Cytometry.
merck millipore,默克密理博,04-142,Anti-IRF4 Antibody, clone 3E4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC, WB, IHC R Purified Monoclonal Antibody 描述 产品目录编号 04-142 描述 Anti-IRF4 Antibody, clone 3E4 Alternate Names - Transcriptional activator PIP
- PU.1 interaction partner
- NF-EM5
- LSIRF
- Lymphocyte-specific interferon regulatory factor
- IRF-4
- Interferon regulatory factor 4
背景信息 Interferon regulatory factor 4, also known as IRF4, belongs to the IRF family. IRF4 encodes a 450 amino acid polypeptide with a predicted molecular weight of 51.6 kDa (Grossman 1996). The IRF4 gene is expressed in the spleen, lymphocytes and melanocytes, and is induced in to T cells after cross linking with the T cell receptor. IRF4 is a transcriptional activator that binds to the interferon stimulated response element (ISRE) of the MHC class I promoter. IRF4 is essential for mature T and B lymphocyte function. IRF4 interacts with MYD88 to prevent the interaction of IRF5, resulting in negative regulation of Toll Like Receptor (TLR) signaling. High levels of IRF4 have been associated with Epstein Barr Virus (EBV) and may be critical to EBV transformation. Further oncogenic potential has been associated with the involvement of IRF4 with hair color and pigmentation of the skin, which may cause multiple myeloma. 产品信息 格式 Purified 演示 Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-IRF4 Antibody, clone 3E4 is a highly specific rat monoclonal antibody, that targets IRF4 & has been tested in western blotting, IHC & Flow Cytometry. 主要应用 - Flow Cytometry
- Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected IRF4 in positive human tonsil tissues.
Flow Cytometry Analysis: A representative lot from an independent laboratory detected IRF4 in wildtype and IRF4 knockout mice (Zheng, Y., et al. (2009). Nature. 458(7236):351-356.).生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the C-terminus of mouse IRF4. 克隆 3E4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_038702
基因符号 - Spip
- Irf4
纯化方法 Protein G purified UniProt编号 - Q64287
产品使用声明 质量保证 Evaluated by Western Blotting in Ramos cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected IRF4 in 10 µg of Ramos cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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