merck millipore,默克密理博,FCMAB385F,Milli-Mark™ Anti-GRK 2/3 (βARK 1/2)-FITC Antibody, clone C5/1.1

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	FC	M	FITC	Monoclonal Antibody

描述
产品目录编号	FCMAB385F
商名	Milli-Mark
描述	Milli-Mark™ Anti-GRK 2/3 (βARK 1/2)-FITC Antibody, clone C5/1.1
Alternate Names	beta adrenergic receptor kinase 1 G-protein coupled receptor kinase 2 adrenergic, beta, receptor kinase 1
背景信息	The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. GRK2 phosphorylates the beta2 adrenergic receptor. It is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors.

产品信息
格式	FITC
控制	HeLa cells
演示	Purified mouse monoclonal IgG2aκ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	Milli-Mark Anti-GRK 2/3 (βARK 1/2)-FITC Antibody, clone C5/1.1 detects level of GRK 2/3 (βARK 1/2) & has been published & validated for use in FC.
主要应用	Flow Cytometry

生物信息
免疫原品种	Partial GST fusion protein corresponding to rat GRK3 (βARK2) at the carboxyl terminus.
表位	carboxyl terminus
克隆	C5/1.1
宿主	Mouse
特异性	Antibody recognizes GRK 2/3.
同种型	IgG2aκ
品种反应性	Human
Species Reactivity Note	Tested and passed on human. Predicted to react with Rat based on immunogen design.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_036908
基因符号	FLJ16718 ADRBK1 Beta-ARK-1 GRK2 BARK
纯化方法	Protein G Purified
UniProt编号	P26817
UniProt汇总	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.

产品使用声明
质量保证	Evaluated by flow cytometry using HeLa cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB385F,Milli-Mark™ Anti-GRK 2/3 (βARK 1/2)-FITC Antibody, clone C5/1.1

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