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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD17 描述 Anti-LGR5 (GPR49) Antibody Alternate Names - G-protein coupled receptor HG38
- Leucine-rich repeat-containing G-protein coupled receptor 5
- G-protein coupled receptor 49
- G-protein coupled receptor 67
背景信息 LGR5 (Leucine-rich repeat G protein-coupled receptor 5) is thought of as a possible stem cell marker for the hair follicle and the epithelium of the intestine. LGR5 is only expressed in cycling crypt base columnar cells, which are thought to be genuine intestinal stem cells. LGR5 has also been implicated as a negative regulator of the Wnt signaling pathway. LGR5 is often up-regulated in certain cancers and may play a role in cancer cell progression. 产品信息 格式 Affinity Purified 控制 - HeLa cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-LGR5 (GPR49) Antibody is an antibody against LGR5 (GPR49) for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human LGR5. 表位 Cytoplasmic Domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes LRG5 at the cytoplasmic domain. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human.
Other homologies: Rat (73% sequence homology). No homology to Mouse was found.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003658
基因符号 - GPR67
- LGR5
- GPR49
纯化方法 Affinity Purified UniProt编号 - O75473
UniProt汇总 FUNCTION: Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.
SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family.
Contains 16 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected LGR5 in 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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