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merck millipore,默克密理博,MABF18,Anti-Interleukin-1 beta (IL-1B) Antibody, clone 4A7
产品名称：Anti-Interleukin-1 beta (IL-1B) Antibody, clone 4A7
产品型号：MABF18
Anti-Interleukin-1 beta (IL-1B) Antibody, clone 4A7 is an antibody against Interleukin-1 beta (IL-1B) for use in WB.
merck millipore,默克密理博,MABF18,Anti-Interleukin-1 beta (IL-1B) Antibody, clone 4A7
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABF18 Replaces 04-462; MABF22 描述 Anti-Interleukin-1 beta (IL-1B) Antibody, clone 4A7 Alternate Names - Catabolin
- interleukin 1, beta
- catabolin
- pro-interleukin-1-beta
- IL-1 beta
- IL1-BETA
- preinterleukin 1 beta
- interleukin-1 beta
背景信息 Interleukin-1 (IL-1) is a cytokine that is thought to be connected to neurodegeneration and in central nervous system-mediated defense reactions to inflammation. Interleukin-1 beta (IL-1B) maintains mitogen-induced proliferation, IL-2 production and expression of IL-2R. IL-1 beta also seems to have the ability to boost the number of cells that move into the G1 phase of the cell cycle. IL-1 beta also has the capacity to stimulate apoptosis on normal human fetal membranes. IL-1 beta may play an important role in inflammation regulating cytokine networks. 产品信息 格式 Purified 控制 - Human Interleukin-1 beta recombinant protein
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Interleukin-1 beta (IL-1B) Antibody, clone 4A7 is an antibody against Interleukin-1 beta (IL-1B) for use in WB. 主要应用 - Western Blotting
应用说明 Luminex Assay Analysis: A previous lot was used by an independent laboratory in Luminex (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX). 生物信息 免疫原品种 Full length recombinant protein corresponding to human Interleukin-1 beta. 克隆 AB34_41.4H12.4A7 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000567
Entrez基因汇总 The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq]. 基因符号 - IL-1
- IL1B
- IL1F2
- IL-1B
纯化方法 Protein G Purified UniProt编号 - P01584
UniProt汇总 FUNCTION: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
SUBUNIT STRUCTURE: Monomer.
SUBCELLULAR LOCATION: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
DOMAIN: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
SEQUENCE SIMILARITIES: Belongs to the IL-1 family.产品使用声明 质量保证 Evaluated by Western Blot in lysate from cells expressing human Interleukin-1 beta recombinant protein.
Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human Interleukin-1 beta recombinant protein.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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