- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,GF030,Glial Derived Neurotrophic Factor Protein, Recombinant human
产品名称：Glial Derived Neurotrophic Factor Protein, Recombinant human
产品型号：GF030
The human Glial Derived Neurotrophic Factor (GDNF) is a 30.4 kDa protein that specifically promotes dopamine uptake & survival of midbrain neurons.
merck millipore,默克密理博,GF030,Glial Derived Neurotrophic Factor Protein, Recombinant human
- 产品介绍
重要规格表
品种 来源 纯度 Human E.coli Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of human GDNF. 描述 产品目录编号 GF030 品牌系列 Chemicon®
商名 - Chemicon
描述 Glial Derived Neurotrophic Factor Protein, Recombinant human 概述 Human Glial Derived Neurotrophic Factor (GDNF) is a 30.4 kDa protein that specifically promotes dopamine uptake and survival of midbrain neurons. GDNF is a disulphide linked homodimeric protein consisting of two 134 amino acid chains. Alternate Names - GDNF
产品信息 演示 Lyophilized from 10 mM Sodium Citrate and 150 mM NaCl. Contains no preservative. 应用 应用 The human Glial Derived Neurotrophic Factor (GDNF) is a 30.4 kDa protein that specifically promotes dopamine uptake & survival of midbrain neurons. 生物信息 纯度 Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of human GDNF. 来源 E.coli 品种 Human 特异活性 Chemicon's human GDNF is fully biologically active when compared to standards as determined by the dose-dependent dopamine uptake by rat ventral mesencephalic cultures. The ED(50) was found to be in the range of 5-10 ng/mL. <br />The ED(50) as determined by the proliferation of rat C6 cells is ≤ 0.1 ng/mL, corresponding to aspecific activity of ≥ 1 x 10<sup>7</sup> units/mg. Entrez基因编号 - NM_199234.1
- NM_000514.2
- NM_199231.1
Entrez基因汇总 This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. 基因符号 - ATF
- GDNF
- HFB1-GDNF
- ATF1
- ATF2
- hGDNF
UniProt编号 - P39905
UniProt汇总 FUNCTION: SwissProt: P39905 # Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
SIZE: 211 amino acids; 23720 Da
SUBUNIT: Homodimer; disulfide-linked.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
DISEASE: SwissProt: P39905 # Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. & Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
SIMILARITY: SwissProt: P39905 ## Belongs to the TGF-beta family. GDNF subfamily.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. The lyophilized power can be reconstituted to 0.1-1.0 mg/mL. This solution can be diluted into water or other buffered solutions. Reconstituted GDNF should be stored in undiluted aliquots at -20°C for up to 6 months. 包装信息 数量 10 µg
上一件merck millipore产品：merck millipore,默克密理博,MAB8051,Anti-Adenovirus Antibody, clone 2/6
下一件merck millipore产品：merck millipore,默克密理博,SCM133,PluriSTEM™ Dispase-II Solution
相关产品
merck millipore,默克密理博,72103,ProteoExtract Glycopeptide Enrichment Kit
merck millipore,默克密理博,MAB5316,Anti-Rhodopsin Antibody, clone RET-P1
merck millipore,默克密理博,MABF18,Anti-Interleukin-1 beta (IL-1B) Antibody, clone 4A7
merck millipore,默克密理博,QIA54,TIMP-1 ELISA Kit
merck millipore,默克密理博,MAB8051,Anti-Adenovirus Antibody, clone 2/6
merck millipore,默克密理博,SCM133,PluriSTEM™ Dispase-II Solution
merck millipore,默克密理博,ABC212,Anti-phospho ULK1 Antibody (Thr574)
merck millipore,默克密理博,ABE569,Anti-monoubiquitin H2A Antibody (Lys119)
merck millipore,默克密理博,AB5430P,Anti-Per3 Antibody
merck millipore,默克密理博,SF-1102,FGFR1; Human, Cyanine 5, RNA Detection Probe,SmartFlare