merck millipore,默克密理愽
  • merck millipore,默克密理博,616452,TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

  • merck millipore,默克密理博,616452,TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

    产品名称：TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem
    产品型号：616452
    The TGF-β RI Kinase Inhibitor II, also referenced under CAS 446859-33-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Deph More>>

    merck millipore,默克密理博,616452,TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616452,TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₃N₅446859-33-2
    描述
    概述 A cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 > 16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158).
    产品目录编号 616452
    品牌系列 Calbiochem®
    同义词 ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
    参考
    参考 Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
    Ichida, J. K., et al. 2009. 5, 491.
    产品信息
    CAS号 446859-33-2
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₁₇H₁₃N₅
    化学配方 C₁₇H₁₃N₅
    Molar Mass 287.3
    结构配方图像
    生物信息
    主靶 ALKS binding
    主靶IC50 23 nM
    副靶 ALK 5 auto phosphorylation (IC₅₀ = 4 nM)
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616452,TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

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