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品种反应性 主要应用 宿主 格式 抗体类型 H FC Rb Phycoerythrin Polyclonal Antibody 描述 产品目录编号 FCABS419PE 商名 - Milli-Mark
描述 Milli-Mark™ Anti-PRMT5-PE Antibody Alternate Names - SKB1 homolog (S. pombe)
- 72 kDa ICln-binding protein
- HMT1 hnRNP methyltransferase-like 5
- Jak-binding protein 1
- SKB1 homolog
背景信息 Arginine methylation of proteins is mediated by the Protein-Arginine Methyl Transferase (PRMT) family of enzymes, which are important in signal transduction, transcription, RNA transport, and splicing. PRMTs are divided into two types defined by their activity. Type I PRMTs (including PRMT 1, 3, 4, and 6) are characterized by the formation of asymmetric dimethylated arginine residues. Type II PRMTs, which include only PRMT5, are defined by the formation of symmetric dimethylated arginine residues. Substrates for PRMT5 include myelin basic protein (MBP) and the spliceosomal D1 and D3 proteins. PRMT5 (also known as Skb1Hs/JBP1) exists as homooligomeric complexes, which includes a dimer and tetramer. Homooligomerization of PRMT5 has an important role in its ability to methylate the MBP protein. 产品信息 格式 Phycoerythrin 控制 - HeLa cells
演示 Purified rabbit polyclonal IgG conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-PRMT5-PE Antibody is an antibody against PRMT5 for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 60-79 (KNRPGPQTRSDLLLSGRDWN) of human protein arginine methyltransferase 5, SKB1 homolog. The immunizing sequence is identical in mouse.
宿主 Rabbit 特异性 Antibody recognizes PRMT5. 同种型 IgG 品种反应性 Human Species Reactivity Note Tested and passed on Human. Unconjugated antibody Cat. No. 07-405 is known to react with Mouse.
抗体类型 Polyclonal Antibody Entrez基因编号 - NP_006100
基因符号 - JBP1
- PRMT5
- HRMT1L5
- IBP72
- SKB1Hs
纯化方法 Protein A Purified UniProt编号 - O14744
UniProt汇总 FUNCTION: SwissProt: O14744 # Methylates specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 to monomethylarginine and to symmetrical dimethylarginines (sDMAs). Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A/H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription.
SIZE: 637 amino acids; 72684 Da
SUBUNIT: Forms, at least, homodimers and homotetramers. Interacts with PRDM1 (By similarity). Component of the methylosome, a 20S complex containing at least pICLn, PRMT1/SKB1 and MEP50. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Also interacts with Sm proteins, JAK2, SSTR1 and SUPT5H. Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Ubiquitous.
PTM: Disulfide bonds and non-covalent association mediate homooligomers formation.
SIMILARITY:SwissProt: O14744 ## Belongs to the protein arginine N-methyltransferase family.产品使用声明 质量保证 Evaluated by flow cytometry using HeLa cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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