merck millipore,默克密理愽
  • merck millipore,默克密理博,AB6017,Anti-F-actin-capping protein subunit beta Antibody

  • merck millipore,默克密理博,AB6017,Anti-F-actin-capping protein subunit beta Antibody

    产品名称：Anti-F-actin-capping protein subunit beta Antibody
    产品型号：AB6017
    Detect F-actin-capping protein subunit beta using this Anti-F-actin-capping protein subunit beta Antibody validated for use in WB & IC.

    merck millipore,默克密理博,AB6017,Anti-F-actin-capping protein subunit beta Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB6017,Anti-F-actin-capping protein subunit beta Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    B, H, M, R, Ca, PmICC, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB6017
    描述 Anti-F-actin-capping protein subunit beta Antibody
    Alternate Names
    • F-actin capping protein beta subunit
    • capping protein (actin filament) muscle Z-line, beta
    背景信息 F-actin-capping-protein subunit beta (CapZ beta) belongs to the F-actin capping protein family, which are characteristic heterodimers, consisting of an α subunit (31-36 kDa) and a β subunit (28-32 kDa), that cap the barbed end of actin filaments within all eukaryotes. Their ability to bind the actin filaments is in a manner independent of Ca2++ and requires the C-terminal end of both subunits for optimal binding. F-actin capping protein subunit beta is contained within the Z-discs of striated muscle, where it functions to inhibit the polymerization and depolymerization of actin. Within vertebrates, there are three isoforms for each of F-actin capping protein subunit beta’s subunits. While there is almost nothing known regarding the β3 subunit, the β1 and β2 isoforms each have distinct roles. The isoform β2 is predominantly expressed in non-muscle cells and is found in intercalated discs and the cell periphery, but is not observed at Z-discs. Isoform β1 is more greatly expressed in striated muscle and is localized at the Z-discs. It also contains the COOH-terminal extension necessary for capping the actin.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
    应用
    应用 Detect F-actin-capping protein subunit beta using this Anti-F-actin-capping protein subunit beta Antibody validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution of the antibody has been shown to detect F-actin-capping protein subunit beta in NIH/3T3 and A431 cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human F-actin-capping protein subunit beta of the C-terminus of isoform 2.
    表位 C-terminus of Isoform 2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 The antibody recognizes F-actin-capping protein subunit beta at the C-terminus of isoform 2.
    品种反应性 BovineHumanMouseRatCaninePrimate
    Species Reactivity Note Demonstrated to react with human, mouse, and rat. Predicted to react with canine, primate, and bovine based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_004921
    Entrez基因汇总 CAPZB is a member of the F-actin capping protein family. This gene encodes the beta subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq].
    基因符号
    • CAZB
    • CAPZ
    • CAPPB
    • CAPB
    • Cap Z
    • CapZ beta
    纯化方法 Protein A purfied
    UniProt编号
    • P47756
    UniProt汇总 FUNCTION: F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

    SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Interacts with ARHGAP17 and RCSD1/CAPZIP. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53.

    SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton (By similarity).

    SEQUENCE SIMILARITIES: Belongs to the F-actin-capping protein beta subunit family.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.1 µg/mL of this antibody detected F-actin-capping protein subunit beta in 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB6017,Anti-F-actin-capping protein subunit beta Antibody

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