merck millipore,默克密理愽
  • merck millipore,默克密理博,203988,Butyrolactone I - CAS 87414-49-1 - Calbiochem

  • merck millipore,默克密理博,203988,Butyrolactone I - CAS 87414-49-1 - Calbiochem

    产品名称：Butyrolactone I - CAS 87414-49-1 - Calbiochem
    产品型号：203988
    A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G₁/S and G₂/M transitions.

    merck millipore,默克密理博,203988,Butyrolactone I - CAS 87414-49-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,203988,Butyrolactone I - CAS 87414-49-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₄H₂₄O₇87414-49-1
    描述
    概述 A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G1/S and G2/M transitions. Inhibits p34cdk1/cyclinB (Cdk1; IC50 = 680 nM). Also selectively inhibits Cdk2 and Cdk5 kinases. Has little effect on casein kinase I, casein kinase II, EGF receptor kinase, MAP kinase, PKA, and PKC. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Also blocks Fas-induced apoptosis in HL-60 cells and shows antitumor effects on human lung cancer cell lines.
    产品目录编号 203988
    品牌系列 Calbiochem®
    参考
    参考 Furukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
    Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
    Kitagawa, M., et al. 1994. Oncogene 9, 2549.
    Kitagawa, M., et al. 1993. Oncogene 8, 2425.
    产品信息
    CAS号 87414-49-1
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₄H₂₄O₇
    Molar Mass 424.5
    可逆 N
    结构配方图像
    生物信息
    主靶 p34cdk1/cyclinB
    主靶IC50 680 nM against Cdk1
    纯度 ≥99% by TLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-20°C).
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,203988,Butyrolactone I - CAS 87414-49-1 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,ABN272,Anti-GPRASP1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,AB6017,Anti-F-actin-capping protein subunit beta Antibody


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