merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1552,Anti-TLS Antibody, clone 1FU-1D2

  • merck millipore,默克密理博,04-1552,Anti-TLS Antibody, clone 1FU-1D2

    产品名称：Anti-TLS Antibody, clone 1FU-1D2
    产品型号：04-1552
    Use Anti-TLS Antibody, clone 1FU-1D2 (Mouse Monoclonal Antibody) validated in WB, ICC to detect TLS also known as 75 kDa DNA-pairing protein, FUS-CHOP fusion protein.

    merck millipore,默克密理博,04-1552,Anti-TLS Antibody, clone 1FU-1D2

  • 产品介绍
  • merck millipore,默克密理博,04-1552,Anti-TLS Antibody, clone 1FU-1D2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 04-1552
    描述 Anti-TLS Antibody, clone 1FU-1D2
    Alternate Names
    • translocated in liposarcoma
    • 75 kDa DNA-pairing protein
    • FUS-CHOP fusion protein
    • FUS-CHOP protein fusion
    • Fusion gene in myxoid liposarcoma
    • Oncogene FUS
    • Oncogene TLS
    • Translocated in liposarcoma protein
    • fus-like protein
    • fus/tls-chop oncogene
    • fusion (involved in t(12
    • 16) in malignant liposarcoma)
    • fusion, derived from t(12
    • 16) malignant liposarcoma
    • heterogeneous nuclear ribonucleoprotein P2
    背景信息 The TLS/FUS protein contains an RNA-recognition motif and is a component of nuclear riboprotein complexes. It resembles a transcription factor in that it binds DNA, contributes a transcriptional activation domain to the FUS-ERG oncoprotein, and interacts with several transcription factors in vitro. It binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. It may play a role in maintenance of genomic integrity.
    产品信息
    格式 Ascites
    控制
    • HepG2 cell lysate
    演示 Unpurified mouse monoclonal IgG1κ preservative-free ascites.
    应用
    应用 Use Anti-TLS Antibody, clone 1FU-1D2 (Mouse Monoclonal Antibody) validated in WB, ICC to detect TLS also known as 75 kDa DNA-pairing protein, FUS-CHOP fusion protein.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis:
    1:500 dilution from a representative lot detected TLS in C2C12 cells.
    生物信息
    免疫原品种 Linear peptide corresponding to human TLS.
    表位 Unknown
    克隆 clone 1FU-1D2
    宿主 Mouse
    特异性 This antibody recognizes TLS.
    同种型 IgG1κ
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_004951.1
    Entrez基因汇总 This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq].
    基因符号
    • hnRNP-P2
    • FUS
    • CHOP
    • FUS-CHOP
    • FUS1
    • POMp75
    • TLS
    • TLS/CHOP
    纯化方法 Unpurified
    UniProt编号
    • P35637
    UniProt汇总 FUNCTION: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.

    SUBUNIT STRUCTURE: Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP.

    SUBCELLULAR LOCATION: Nucleus

    TISSUE SPECIFICITY: Ubiquitous.

    PTM: Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.

    INVOLVEMENT IN DISEASE: A chromosomal aberration involving FUS is a cause of a form of malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3.

    A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG.

    A chromosomal aberration involving FUS is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein.

    Defects in FUS are the cause of amyotrophic lateral sclerosis type 6 (ALS6) [MIM:608030]. ALS6 is a familial form of amyotrophic lateral sclerosis. ALS is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10%.

    SEQUENCE SIMILARITIES: Belongs to the RRM TET family.

    Contains 1 RanBP2-type zinc finger.

    Contains 1 RRM (RNA recognition motif) domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HepG2 cell lysate.

    Western Blot Analysis: 1:1,000 dilution of this antibody detected TLS on 10 µg of HepG2 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-1552,Anti-TLS Antibody, clone 1FU-1D2

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