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品种反应性 主要应用 宿主 格式 抗体类型 R, Rb, B, Ca, H, Mk FC Rb FITC Polyclonal Antibody 描述 产品目录编号 FCABS332F 商名 - Milli-Mark
描述 Milli-Mark™ Anti-NR2B-FITC Antibody Alternate Names - glutamate receptor, ionotropic, N-methyl D-aspartate 2B
- N-methyl D-aspartate receptor subtype 2B
- N-methyl-D-aspartate receptor subunit 2B
- N-methyl-D-aspartate receptor subunit 3
- glutamate receptor subunit epsilon-2
背景信息 NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B or NR2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death. 产品信息 格式 FITC 控制 - B35 cells
演示 Purified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-NR2B-FITC Antibody detects level of NR2B & has been published & validated for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Linear peptide corresponding to mouse NR2B. 宿主 Rabbit 特异性 Antibody recognizes Mouse NR2B. 同种型 IgG 品种反应性 RatRabbitBovineCanineHumanMonkey Species Reactivity Note Tested and passed on Rabbit. Predicted on Bovine, Canine, Human, Monkey, Rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000825
基因符号 - GRIN2B
- MGC142178
- MGC142180
- NMDAR2B
- NR3
- hNR3
纯化方法 Protein A Purified UniProt编号 - Q13224
UniProt汇总 FUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
SIZE: 1484 amino acids; 166367 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.产品使用声明 质量保证 Evaluated by flow cytometry using B35 cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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