merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1356,Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10

  • merck millipore,默克密理博,MAB1356,Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10

    产品名称：Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10
    产品型号：MAB1356
    Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10 detects level of Integrin α6A & has been published & validated for use in WB, IC, IH.

    merck millipore,默克密理博,MAB1356,Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10

  • 产品介绍
  • merck millipore,默克密理博,MAB1356,Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1356
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10
    Alternate Names
    • CD49f
    背景信息 Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrin function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha 3 and alpha6, two cytoplasmic variants, A and B, have been identified.
    产品信息
    格式 Purified
    演示 Purified. Liquid in PBS containing 0.01% sodium azide.
    应用
    应用 Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10 detects level of Integrin α6A & has been published & validated for use in WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western blotting: 1:100-1:500

    Immunocytochemistry: 1:50-1:100

    Immunohistochemistry: 1:50-1:100

    Optimal dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to the cytoplasmic C-terminal 28 amino acids including an appending N-terminal cysteine:CKKDHYDATYHKAEIHAQPSDKERLTSDA.
    表位 cytoplasmic domain
    克隆 1A10
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 MAB1356 reacts exclusively with the cytoplasmic domain of non-phosphorylated integrin subunit alpha 6A. The antibody stains the basement membrane zone of skin, myoepithelial cells in sweat glands, peripheral nerves, sebaceous glands and some blood vessels in the dermis.

    Brroad species reactivity is expected because of the conserved nature of the epitope.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001079818.1
    • NM_000210.2
    Entrez基因汇总 The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • CD49f
    • ITGA6
    • VLA-6
    • ITGA6B
    UniProt编号
    • P23229
    UniProt汇总 FUNCTION: SwissProt: P23229 # Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
    SIZE: 1130 amino acids; 126619 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
    PTM: Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
    DISEASE: "SwissProt: P23229 # Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB-PA) [MIM:226730]; also known as aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive disease characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus."
    SIMILARITY: SwissProt: P23229 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C for 3-4 weeks or long term at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1356,Anti-Integrin α6A Antibody, cytoplasmic domain, clone 1A10

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