merck millipore,默克密理愽
  • merck millipore,默克密理博,07-820,Anti-phospho-EGFR (Tyr845) Antibody

  • merck millipore,默克密理博,07-820,Anti-phospho-EGFR (Tyr845) Antibody

    产品名称：Anti-phospho-EGFR (Tyr845) Antibody
    产品型号：07-820
    This Anti-phospho-EGFR (Tyr845) Antibody is validated for use in IC, IF, IH, WB for the detection of phospho-EGFR (Tyr845).

    merck millipore,默克密理博,07-820,Anti-phospho-EGFR (Tyr845) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-820,Anti-phospho-EGFR (Tyr845) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ICC, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-820
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-EGFR (Tyr845) Antibody
    产品信息
    格式 Affinity Purified
    控制
    • EGF stimulated A431 cells
    演示 Affinity Purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
    应用
    应用 This Anti-phospho-EGFR (Tyr845) Antibody is validated for use in IC, IF, IH, WB for the detection of phospho-EGFR (Tyr845).
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunoblot Analysis: A 1:1000 dilution of this lot detected phospho-EGFR (Tyr845) in RIPA lysates from EGF stimulated A431 cells.
    生物信息
    免疫原品种 Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-EGFR (Tyr845)
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes phospho-EGFR (Tyr845).
    品种反应性 Human
    Species Reactivity Note Predicted to cross-react with mouse and rat based on sequence homology (100%), but have not been tested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_201284.1
    • NM_005228.3
    • NM_201282.1
    • NM_201283.1
    基因符号
    • mENA
    • EGFR
    • ERBB1
    • ERBB
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P00533
    UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
    SIZE: 1210 amino acids; 134277 Da
    SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
    TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
    PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
    SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-820,Anti-phospho-EGFR (Tyr845) Antibody

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