merck millipore,默克密理博,528244,Platensimycin, Streptomyces sp. - CAS 835876-32-9

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merck millipore,默克密理博,528244,Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem
产品名称：Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem
产品型号：528244
A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF.

merck millipore,默克密理博,528244,Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem

产品介绍

merck millipore,默克密理博,528244,Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem

重要规格表

经验配方	CAS号
C₂₄H₂₇NO₇	835876-32-9

描述
概述	A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF (IC₅₀ = 48 and 160 nM against S. aureus and E. coli FabF, respectively), but not the initiation condensing enzyme FabH (IC₅₀ = 67 µM), involved in type II fatty acid synthesis (FASII). Binding studies indicate that acyl-FabF intermediate complex formation induces a FabF conformation change that is necessary for Platensimycin interaction. Platensimycin effectively kills numerous Staphylococcus aureus, Enterococcus faecium, and Streptococcus pneumoniae strains, including the ones that are resistant to methicillin and vancomycin (Cat. No. 627850). Platensimycin does not exhibit antifungal activity towards Candida albicans (no effect at 64 µg/ml) or toxicity toward mammalian HeLa culture (no effect at 1000 µg/ml) and is efficacious in treating S. aureus infection in mice in vivo (~10⁵-fold bacteria titre reduction via a 24 h i.v. at 150 µg h^-1). Although Platensimycin is ineffective toward wild-type E. coli due to the presence of functional multidrug efflux pump (no effect at 64 µg/ml), Platensimycin does inhibit the growth of efflux-negative E. coli strains. Platensimycin has been shown to potently and selectively inhibit hepatocyte FAS and fatty acid oxidation (FAO), without affecting sterol synthesis. Platensimycin is also known as Fatty Acid Synthase Inhibitor III.
产品目录编号	528244
品牌系列	Calbiochem®

参考
参考	Wu, M., et al. 2011. Proc. Natl. Acad. Sci. USA in press. Wang, J., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7612. Singh, S.B., et al. 2006. J. Am. Chem. Soc. 128, 11916. Wang, J., et al. 2006. Nature 441, 358.

产品信息
CAS号	835876-32-9
形式	Tan solid
Hill配方	C₂₄H₂₇NO₇
化学配方	C₂₄H₂₇NO₇
Molar Mass	441.5
结构配方图像

生物信息
纯度	≥93% by HPLC

理化信息
溶解度	DMSO or EtOH

安全信息
R相	R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
S相	S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Harmful
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.