merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB390-25UG,Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192

  • merck millipore,默克密理博,MAB390-25UG,Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192

    产品名称：Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192
    产品型号：MAB390-25UG
    This Anti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 is validated for use in ICC, IHC(P), FUNC for the detection of p75 Low Affinity Nerve Growth Factor Rece More>>

    merck millipore,默克密理博,MAB390-25UG,Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192

  • 产品介绍
  • merck millipore,默克密理博,MAB390-25UG,Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RICCMSaporinMonoclonal Antibody
    描述
    产品目录编号 MAB390-25UG
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192
    Alternate Names
    • p75 ICD
    • nerve growth factor receptor (TNFR superfamily, member 16)
    • nerve growth factor receptor
    • low affinity nerve growth factor receptor
    • NGF receptor
    • Low-affinity nerve growth factor receptor
    • Low affinity neurotrophin receptor p75NTR
    • CD271 antigen
    • member 16)
    背景信息 The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. The neurotrophins are comprised of four proteins, all of which bind to the LNGFR: Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4. Nerve growth factor, the prototypical growth factor, is a protein secreted by a neuron's target. NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the cell body. This movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons.
    产品信息
    格式 Saporin
    控制
    • Brain tissue
    演示 Saporin Conjugated. 192-IgG-SAP is sterile filtered and presented in Dulbecco's PBS with no preservative.
    应用
    应用 This Anti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 is validated for use in ICC, IHC(P), FUNC for the detection of p75 Low Affinity Nerve Growth Factor Receptor.
    主要应用
    • Immunocytochemistry
    应用说明 Immunohistochemistry (Paraffin):
    A previous lot of this antibody was used in IH(P).

    Immunocytochemistry:
    A previous lot of this antibody was used in IC.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 p75-expressing cells
    克隆 192
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes the rat NGF receptor (p75, low affinity Neurotrophin Receptor). MAB365 is the monoclonal antibody used for MAB390-SAP.
    同种型 IgG1
    品种反应性 Rat
    Species Reactivity Note Rat, not reactive to human or mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002507.2
    Entrez基因汇总 Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
    基因符号
    • CD271
    • NGFR
    • p75(NTR)
    • TNFRSF16
    • Gp80-LNGFR
    非反应性品种
    • Mouse
    • Human
    纯化方法 Protein A purfied
    UniProt编号
    • P08138
    UniProt汇总 FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
    SIZE: 427 amino acids; 45183 Da
    SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
    PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
    SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 25 µg

    merck millipore,默克密理博,MAB390-25UG,Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192

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