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品种反应性 主要应用 宿主 格式 抗体类型 R WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15614-200UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CNGA3 Antibody Alternate Names - Anti-Cyclic nucleotide-gated channel, CNG3
- Anti-Cyclic nucleotide-gated channel
产品信息 格式 Affinity Purified 控制 - Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 Detect CNGA3 using this Anti-CNGA3 Antibody validated for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western blot: 1:200 using ECL on rat brain membrane lysate.
Immunohistochemistry on frozen rat brain sections.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified peptide from the C-terminus of rat CNGA3 (Accession number Q9QWN7). 宿主 Rabbit 特异性 Recognizes CNGA3 (Cyclic nucleotide-gated channel, CNG3). 品种反应性 Rat Species Reactivity Note The immunogen sequence is 15 of 18 amino acids identical in mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001298.2
- NM_001079878.1
Entrez基因汇总 This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. 基因符号 - CNG-3
- CNGA3
- CNCG3
- CCNCalpha
- CNG3
- CCNCa
- ACHM2
- CCNC1
纯化方法 Immunoaffinity purified UniProt编号 - Q16281
UniProt汇总 FUNCTION: SwissProt: Q16281 # Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
SIZE: 694 amino acids; 78838 Da
SUBUNIT: Heterooligomeric complex with CNGB3.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Prominently expressed in retina.
DISEASE: SwissProt: Q16281 # Defects in CNGA3 are a cause of achromatopsia type 2 (ACHM2) [MIM:216900]; also known as total colorblindness or rod monochromacy (RMCH2). ACHM2 is an autosomal recessive condition characterized by day blindness and photophobia. In ACHM2 patients the cones are defective and the subjects see better at night.
SIMILARITY: SwissProt: Q16281 ## Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. & Contains 1 cyclic nucleotide-binding domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 200 µL
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