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经验配方 CAS号 C₁₀H₇N₅OS 62645-28-7 描述 概述 A cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. Acts as a highly selective, irreversible inhibitor of IκBαee ubiquitination (IC50 = 2.3 µM). Blocks NF-κB-dependent cytokine expression in human PBMNs (IC50’s = ~ 700 nM for TNF-α, IL-1β, and IL-6 inhibition) and rats. Does not inhibit SCFβTRCP(IκBα ubiquitin ligase)-mediated β-catenin ubiquitination in Jurkat cells. At 10 µM concentrations, also inhibits the activities of 5-lipoxygenase (by 89%) and EGFR kinase (by 63%). 产品目录编号 557550 品牌系列 Calbiochem®
参考 参考 Swinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573. 产品信息 CAS号 62645-28-7 具有ATP竞争性 N 形式 White solid Hill配方 C₁₀H₇N₅OS 化学配方 C₁₀H₇N₅OS Molar Mass 245.3 可逆 N 结构配方图像 生物信息 主靶 IκBαee ubiquitination 主靶IC50 2.3 µM against IκBαee ubiquitination 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避光 Protect from light
防潮 Protect from moisture
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. 包装信息 惰性气体下包装 Packaged under inert gas
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