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品种反应性 主要应用 宿主 格式 抗体类型 M, H FC Rb Purified Polyclonal Antibody 描述 产品目录编号 CBL776 Replaces AB1367 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-c-fms oncoprotein Antibody Alternate Names - CSF-1R
- M-CSF
- CD115
产品信息 格式 Purified 演示 The purified immunoglobulin is presented at a concentration of 100μg/ml in phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 Anti-c-fms oncoprotein Antibody is an antibody against c-fms oncoprotein for use in FC, IH(P). 主要应用 - Flow Cytometry
应用说明 Immunocytochemistry
Immunohistochemistry on formaline-fixed paraffin-embedded tissue sections.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide: Ser-Leu-Pro-Arg-Leu-Lys-Arg-Ser-Glu-Ser-Gly-Arg-Tyr selected from the external domain of the feline v-fms sequence (amino acids 399-411). 宿主 Rabbit 特异性 The purified antibody has been used to detect c-fms oncoprotein in formalin fixed paraffin wax embedded tissue sections.
KNOWN SPECIES CROSS REACTIVITY: Known to detect c-fms on either fresh frozen or formalin fixed mouse macrophages.品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005211.2
Entrez基因汇总 The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. 基因符号 - CSF-1R
- CSF1R
- C-FMS
- FMS
- FIM2
- CSF-1-R
- CSFR
- c-fms
- CD115
- EC 2.7.10.1
UniProt编号 - P07333
UniProt汇总 FUNCTION: SwissProt: P07333 # This protein is the receptor for CSF-1, it is a protein tyrosine-kinase transmembrane receptor.
SIZE: 972 amino acids; 107984 Da
SUBUNIT: Interacts with INPPL1/SHIP2 and THOC5 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in bone marrow and in differentiated blood mononuclear cells.
SIMILARITY: SwissProt: P07333 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 100 µg
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