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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB10524 描述 Anti-EBF-2 Antibody Alternate Names - Short name=OE-3
- Transcription factor COE2
- Early B-cell factor 2
- EBF-2
- Metencephalon-mesencephalon-olfactory transcription factor 1
- MET-mesencephalon-olfactory TF1
- Short name=MET-mesencephalon-olfactory transcription factor 1
- Olf-1/EBF-like 3
- Short name=O/E-3
背景信息 The family of Early B-cell Factor (EBF) or Collier/Olf-1/EBF (COE) proteins, EBF1, EBF2, and EBF3, are ubiquitous zinc-binding transcription factors found in many species, including human, Drosophila melanogaster, and Caenorhabditis elegans. EBF proteins are capable of forming homo- and heterodimers that bind to DNA at specific sites that include the sequence 5'-ATTCCCNNGGGAATT-3'. EBF1, the prototypical member of this family, may employ epigenetic mechanisms, such as DNA methylation and chromatin remodeling, to regulate genes involved in B-cell development such as Pax5. The second member of this family EBF2 is involved in bone development, adipogenesis, and CNS development, processes which may also hinge on EBF1. EBF3 has been characterized as a tumor suppressor protein, due to its role in regulating multiple genes such as those for cyclins and CDKs which control cell growth, differentiation, and apoptosis. However, emerging evidence indicates that all EBF proteins may play a role in the development of various cancers. 产品信息 格式 Affinity Purified 控制 - EBF-1, EBF-2, and EBF-3 peptides
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-EBF-2 Antibody detects level of EBF-2 & has been published & validated for use in Western Blotting, IHC(P), Dot Blot. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: A 1:500 dilution from a representative lot detected EBF-2 in COS-7 cells transfected with EBF-2. (Image courtesy of Dr. Giacomo Consalez, San Raffaele Scientific Institute.)
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected EBF-2 in mouse cryosections of wild type spinal cord tissue. (Image courtesy of Dr. Giacomo Consalez, San Raffaele Scientific Institute.)
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse EBF-2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes EBF-2 but not EBF-1 or EBF-3. 品种反应性 Mouse Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Human, Rat, Bovine, and Rhesus Macaque based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_034225
基因符号 - Mmot1
- Ebf2
- Coe2
纯化方法 Affinity purified UniProt编号 - O08792
产品使用声明 质量保证 Evaluated by Dot Blot in EBF-1, EBF-2, and EBF-3 peptides.
Dot Blot Analysis: 1 µg/mL of this antibody detected EBF-2 in 10 µg of EBF-2 peptides.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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