merck millipore,默克密理博,ABC67,Anti-Mitochondrial fission 1 protein (Fis1) Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABC67
描述	Anti-Mitochondrial fission 1 protein (Fis1) Antibody
Alternate Names	TPR repeat protein 11 FIS1 homolog hFis1 Tetratricopeptide repeat protein 11
背景信息	Mitochondrial fission 1 protein, hFIs1, is an overexpressed mammlian protein that is localized to the outer mitochondrial membrane of various cell types. It is involved in the fragmentation of the mitochondrial network and its perinuclear clustering, resulting in the release of cytochrome c from the mitochondrion, and apopotosis. It is known to mediate peroxisomal fission and also plays a critical role in histone function by demethylating Lys-4 of histone H3.

产品信息
格式	Affinity Purified
控制	Raji cell lysate
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect Mitochondrial fission 1 protein (Fis1) using this Anti-Mitochondrial fission 1 protein (Fis1) Antibody validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated-linear peptide corresponding to the cytoplasmic topological domain of human Mitochondrial fission 1 protein.
表位	Cytoplasmic topological domain
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody recognizes the cytoplasmic topological domain of Mitochondrial fission 1 protein.
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human. Other homologies: Rat and Mouse (83% sequence homology).
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_057152
Entrez基因汇总	The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission.
基因符号	CGI-135 FIS1 TTC11
纯化方法	Affinity Purified
UniProt编号	Q9Y3D6
UniProt汇总	FUNCTION: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. SUBUNIT STRUCTURE: Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5. SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.

产品使用声明
质量保证	Evaluated by Western Blot in Raji cell lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitochondrial fission 1 protein in 10 µg of Raji cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,ABC67,Anti-Mitochondrial fission 1 protein (Fis1) Antibody

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