merck millipore,默克密理愽
  • merck millipore,默克密理博,566327,SIRT1/2 Inhibitor VII - CAS 143034-06-4 - Calbiochem

  • merck millipore,默克密理博,566327,SIRT1/2 Inhibitor VII - CAS 143034-06-4 - Calbiochem

    产品名称：SIRT1/2 Inhibitor VII - CAS 143034-06-4 - Calbiochem
    产品型号：566327
    The SIRT1/2 Inhibitor VII, also referenced under CAS 143034-06-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,566327,SIRT1/2 Inhibitor VII - CAS 143034-06-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,566327,SIRT1/2 Inhibitor VII - CAS 143034-06-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₀N₂O₂S143034-06-4
    描述
    概述 A thiobarbiturate compound that acts as an inhibitor against sirtuins (IC50 = 13.2 & 9.1 µM using human SIRT1 & SIRT2, respectively), the NAD+-dependent class III histone deacetylases (HDACs). Computer-aided molecular structural anaylsis reveals that both hydrogen bonds and van der Waals type of interactions contribute to the successful docking of the inhibitor into the nicotinamde subpocket of SIRT2 with the bulky naphthyl group being placed directly into the acetyllysine substrate channel.
    产品目录编号 566327
    品牌系列 Calbiochem®
    同义词 5-(2-Naphthylidine)-2-thiobarbituric acid, SIRT1 Inhibitor V, SIRT2 Inhibitor VII
    参考
    参考 Uciechowska, U., et al. 2008. ChemMedChem 3, 1965.
    产品信息
    CAS号 143034-06-4
    形式 White to off-white solid
    Hill配方 C₁₅H₁₀N₂O₂S
    化学配方 C₁₅H₁₀N₂O₂S
    Molar Mass 282.3
    结构配方图像
    生物信息
    纯度 ≥95% by NMR
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,566327,SIRT1/2 Inhibitor VII - CAS 143034-06-4 - Calbiochem

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