merck millipore,默克密理博,598510,DL-Thiorphan - CAS 76721-89-6

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merck millipore,默克密理博,598510,DL-Thiorphan - CAS 76721-89-6 - Calbiochem
产品名称：DL-Thiorphan - CAS 76721-89-6 - Calbiochem
产品型号：598510
A thiol containing amido-acid that selectively binds to the active site zinc of metalloproteinases and blocks their activity (IC₅₀ = 2.1 nM for neutral endopeptidase-NEP).

merck millipore,默克密理博,598510,DL-Thiorphan - CAS 76721-89-6 - Calbiochem

产品介绍

merck millipore,默克密理博,598510,DL-Thiorphan - CAS 76721-89-6 - Calbiochem

重要规格表

经验配方	CAS号
C₁₂H₁₅NO₃S	76721-89-6

描述
概述	A thiol containing amido-acid that selectively binds to the active site zinc of metalloproteinases and blocks their activity (IC₅₀ = 2.1 nM for neutral endopeptidase-NEP). Although it is shown to inhibit the activity for Aβ peptide degrading enzyme neprilysin in vitro, it has no effect on the secretion of Aβ peptide or amyloid β precursor protein (APP). Also reported to inhibit the activity of angiotensin-converting enzyme (ACE) at much higher concentrations (IC₅₀ = 140 nM); however, it does not affect the activity of endothelin-converting enzyme.
产品目录编号	598510
品牌系列	Calbiochem®
同义词	N-[(RS)-2-Benzyl-3-mercaptopropanoyl]-glycine

参考
参考	Eckman, E.A., et al. 2001. J. Bio. Chem. 276, 24540. Iwata, N., et al. 2001. Science 292, 1550. Shirotani, K., et al. 2001. J. Biol. Chem. 276, 21895. Ghaddar, G., et al. 2000. Biochem. J. 347, 419. Iwata, N., et al. 2000. Nature Med. 6, 143. Takaki, Y., et al. 2000. J. Biochem. 128, 897. Fuller, S.J., et al. 1995. Biochemistry 34, 8091. Sajid, M., et al. 1995. Parasitology. 111, 599. Gomez-Monterrey, I., et al. 1994. J. Med. Chem. 37, 1865. Takahashi, M., et al. 1993. J. Biol. Chem. 268, 21394. Roderick, S.L., et al. 1989. Biochemistry 28, 1493.

参考

Eckman, E.A., et al. 2001. J. Bio. Chem. 276, 24540.
Iwata, N., et al. 2001. Science 292, 1550.
Shirotani, K., et al. 2001. J. Biol. Chem. 276, 21895.
Ghaddar, G., et al. 2000. Biochem. J. 347, 419.
Iwata, N., et al. 2000. Nature Med. 6, 143.
Takaki, Y., et al. 2000. J. Biochem. 128, 897.
Fuller, S.J., et al. 1995. Biochemistry 34, 8091.
Sajid, M., et al. 1995. Parasitology. 111, 599.
Gomez-Monterrey, I., et al. 1994. J. Med. Chem. 37, 1865.
Takahashi, M., et al. 1993. J. Biol. Chem. 268, 21394.
Roderick, S.L., et al. 1989. Biochemistry 28, 1493.

产品信息
CAS号	76721-89-6
具有ATP竞争性	N
形式	White solid
Hill配方	C₁₂H₁₅NO₃S
化学配方	C₁₂H₁₅NO₃S
Molar Mass	253.3
可逆	N
结构配方图像

生物信息
主靶	NEP activity
主靶IC₅₀	2.1 nM for neutral endopeptidase-NEP
纯度	≥95% by TLC

理化信息
细胞可渗透	N
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
防潮	Protect from moisture
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 weeks at -20°C.