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主要应用 Entrez基因编号 Uni Prot编号 WB NM_181505.2, NM_032192.2 Q9UD71 描述 产品目录编号 AG657 品牌系列 Chemicon®
商名 - Chemicon
描述 DARPP-32, recombinant, His-tagged 产品信息 演示 0.5 mg/mL in Tris-buffered saline containing 40% glycerol. 应用 主要应用 - Western Blotting
应用说明 Phosphatase assays 生物信息 纯度 >90% by SDS-PAGE 来源 Recombinant human DARPP-32, expressed in bacteria with a His-Tag linker. 品种 Human Entrez基因编号 - NM_181505.2
- NM_032192.2
Entrez基因汇总 Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM] 基因符号 - DARPP32
- PPP1R1B
- DARPP-32
- FLJ20940
UniProt编号 - Q9UD71
UniProt汇总 FUNCTION: SwissProt: Q9UD71 # Inhibitor of protein-phosphatase 1.
SIZE: 204 amino acids; 22963 Da
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Dopamine- and cyclic AMP-regulated neuronal phosphoprotein. & Phosphorylation of Thr-34 is required for activity (By similarity).
SIMILARITY: SwissProt: Q9UD71 ## Belongs to the protein phosphatase inhibitor 1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20°C for up to 1 year. 包装信息 数量 50 µg
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