merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL191,Anti-Complement C3a Antibody, clone H13

  • merck millipore,默克密理博,CBL191,Anti-Complement C3a Antibody, clone H13

    产品名称：Anti-Complement C3a Antibody, clone H13
    产品型号：CBL191
    This Anti-Complement C3a Antibody, clone H13 is validated for use in ELISA, IH, WB for the detection of Complement C3a.

    merck millipore,默克密理博,CBL191,Anti-Complement C3a Antibody, clone H13

  • 产品介绍
  • merck millipore,默克密理博,CBL191,Anti-Complement C3a Antibody, clone H13

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rb, Gp, HWB, ELISA, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL191
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Complement C3a Antibody, clone H13
    产品信息
    格式 Purified
    演示 Protein A purified immunoglobulin lyophilized from PBS, pH 7.4, containing 0.5% BSA and 0.09% sodium azide. Reconstitute with 1 mL distilled water.
    应用
    应用 This Anti-Complement C3a Antibody, clone H13 is validated for use in ELISA, IH, WB for the detection of Complement C3a.
    主要应用
    • Western Blotting
    • ELISA
    • Immunohistochemistry
    生物信息
    免疫原品种 Human complement component C3
    克隆 H13
    宿主 Mouse
    特异性 The antibody recognizes an epitope on the alpha-chain of Complement C3 (Western blot). The antibody inhibits the anaphylactic function of C3a: the capacity of C3a to induce serotonin release from thrombocytes in vitro is inhibited; similarly, treatment of C3a with the antibody inhibits the C3a-induced skin reaction in vivo. The antibody is, in combination with antibodies to the C3b fragment, an excellent control for distinguishing ubiquitous or nonspecifically bound native C3 from the biologically active C3 fragment. Nonactivated C3 still bears the C3a determinant, whereas activated C3 (C3b, C3d) is C3a-negative. It is therefore useful for immunopathological assays (demonstration of C3 deposition in biopsies) and for C3a assays.
    同种型 IgG2b
    品种反应性 RabbitGuinea PigHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000064.2
    Entrez基因汇总 Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptable to bacteria infection.
    基因符号
    • CPAMD1
    • C3
    • ASP
    • ARMD9
    UniProt编号
    • P01024
    UniProt汇总 FUNCTION: SwissProt: P01024 # Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
    SIZE: 1663 amino acids; 187148 Da
    SUBUNIT: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with CR2 and VSIG4.
    SUBCELLULAR LOCATION: Secreted.
    PTM: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g.
    DISEASE: SwissProt: P01024 # Defects in C3 are the cause of C3 deficiency [MIM:120700]. It can result in susceptibility to pyogenic infection. & Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9) [MIM:611378]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
    SIMILARITY: SwissProt: P01024 ## Contains 1 anaphylatoxin-like domain. & Contains 1 NTR domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2°-8°C for up to 12 months from date of receipt.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,CBL191,Anti-Complement C3a Antibody, clone H13

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