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merck millipore,默克密理博,EZGLP1T-36K,Multi Species GLP-1 Total ELISA, EZGLP1T-36K
产品名称：Multi Species GLP-1 Total ELISA, EZGLP1T-36K
产品型号：EZGLP1T-36K
This Multi Species GLP-1 Total ELISA, EZGLP1T-36K is used to measure & quantify Glucagon Like Peptide-1 levels in Metabolism research.
merck millipore,默克密理博,EZGLP1T-36K,Multi Species GLP-1 Total ELISA, EZGLP1T-36K
- 产品介绍
重要规格表
可用的分析物 品种反应性 主要应用 Glucagon Like Peptide-1 R, H, M ELISA 描述 产品目录编号 EZGLP1T-36K 描述 Multi Species GLP-1 Total ELISA, EZGLP1T-36K 背景信息 Glucagon-like peptide-1 (GLP-1) is a 30 amino acid gut hormone secreted from the intestinal L-cells. The GLP-1 sequence is highly conserved among mammals and is released in its active form (7-36) in response to food intake. It is quickly degraded into its inactive form (9-36) after cleavage by DPPIV. GLP-1 reduces glucose levels by regulating pancreatic secretion, slowing gastric emptying and lowering the desire for food intake. Therefore, it is an important biomarker for the study of diabetes and obesity. This kit measures both the active (7-36) and inactive (9-36) forms of GLP-1. 产品信息 精度（%） - Inter-assay:< 12%
- Intra-assay: < 5%
应用 应用 This Multi Species GLP-1 Total ELISA, EZGLP1T-36K is used to measure & quantify Glucagon Like Peptide-1 levels in Metabolism research. 主要应用 - ELISA
应用说明 This is a 3.5-hour assay at room temperature requiring 50 uL of serum, plasma or culture samples per well. 生物信息 特异性 The antibody pair used in this assay is specific to GLP-1 (7-36) and (9-36) and has no cross-reactivity with GLP-2, GIP, Glucagon or Oxyntomodulin. 品种反应性 RatHumanMouse 可用的分析物 - Glucagon Like Peptide-1
交叉反应性 GLP-1 is conserved in almost all mammals. Entrez基因编号 - NM_002054.2
Entrez基因汇总 The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. 基因符号 - glucagon
- GCG
- GRPP
- GLP1
- GLP2
UniProt编号 - P01275
UniProt汇总 FUNCTION: SwissProt: P01275 # Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
SIZE: 180 amino acids; 20909 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
PTM: Proglucagon is post-translationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
SIMILARITY: SwissProt: P01275 ## Belongs to the glucagon family.
MISCELLANEOUS: In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.准确度 - Linearity 90 - 132%
- Recovery: 90 - 110%
理化信息 灵敏度 - MinDC is 1.5 pM
标准曲线范围 - 4.1 – 1000 pM
包装信息 数量 96-well plate
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