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描述 产品目录编号 AP512 描述 Sheep Anti-Human IgM, (Fc) Antibody Alternate Names - Ig mu chain C region
背景信息 Immunoglobin M (IgM) antibody is prominent in early immune responses to most antigens and is the predominant response in certain antibody responses such as "natural" blood group antibodies. IgM is the major immunoglobin expressed on surface B lymphocytes. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. 产品信息 格式 Purified 控制 - Human IgG, Human IgG Fab Fragment, Human IgG Fc, Human IgM Fc, Human IgM (myeloma) Fab m fragment, Human IgA, Mouse IgM, Rat IgM whole molecule, Chicken IgM whole molecule, Goat IgM whole molecule, Guinea Pig IgM whole molecule, Hamster IgM whole molecule, and Rabbit IgM whole molecule
演示 Purified sheep polyclonal in PBS containing 0.05% sodium azide. Depleted against rabbit IgM and human IgG. 应用 应用 Sheep anti-Human IgM, (Fc) Antibody is an antibody against Human IgM, (Fc) for use in ELISA. 主要应用 - ELISA
生物信息 免疫原品种 Human anti-Human IgM (myeloma) Fc5u fragment 表位 IgM, (Fc) 宿主 Sheep 特异性 This antibody reacts with human IgM, (Fc) as demonstrated by ELISA. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. No reactivity with IgG or IgA. May react with IgM of other species with low specificity. 抗体类型 Polyclonal Antibody 基因符号 - IGHM
纯化方法 Depletion UniProt编号 - P01871
UniProt汇总 FUNCTION: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as an homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
SUBUNIT STRUCTURE: Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon, gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant region. An IgM molecule contains thus a mu heavy chain combined with either a kappa or a lambda light chains. It is found almost exclusively as an homopentamer in the serum. Membrane-bound IgM molecules are non-covalently associated with heterodimer of CD79A and CD79B.
SUBCELLULAR LOCATION: Isoform 1: Secreted. Note: During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
POLYMORPHISM: All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 215 have been observed in human mu chains.
INVOLVEMENT IN DISEASE: Defects in IGHM are the cause of agammaglobulinemia type 1 (AGM1) [MIM:601495]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Ref.10
SEQUENCE CAUTION: The sequence CAA33071.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA34971.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.产品使用声明 质量保证 Evaluated by ELISA against Human IgG, Human IgG Fab Fragment, Human IgG Fc, Human IgM Fc, Human IgM (myeloma) Fab m fragment, Human IgA, Mouse IgM, Rat IgM whole molecule, Chicken IgM whole molecule, Goat IgM whole molecule, Guinea Pig IgM whole molecule, Hamster IgM whole molecule, and Rabbit IgM whole molecule.
ELISA Analysis: A representative lot detected Sheep Anti-Human IgM, (Fc) in ELISA.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 500 µg
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