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经验配方 CAS号 C₈H₁₆N₂O₄ 38937-66-5 描述 概述 A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Causes an increase in acetylated histone H4 in MEL cells and inhibits the human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that acts both as inducers of differentiation of transformed cells and apoptosis. Suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively). 产品目录编号 559418 品牌系列 Calbiochem®
同义词 Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII 参考 参考 Brinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.
Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.产品信息 CAS号 38937-66-5 具有ATP竞争性 N 声明 Not available for sale in the United States. 形式 White solid Hill配方 C₈H₁₆N₂O₄ 化学配方 C₈H₁₆N₂O₄ Molar Mass 204.2 可逆 N 结构配方图像 生物信息 主靶 human HDAC1 and HDAC3 activities 主靶IC50 11.57 µM and 5.39 µM in suppressing the growth of proliferating keratinocytes and squamous cell carcinoma cells, respectively 纯度 ≥98% by TLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
From Catalog:
Desc. Field- added "cell-permeable包装信息 惰性气体下包装 Packaged under inert gas
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