merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB282F,Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC

  • merck millipore,默克密理博,FCMAB282F,Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC

    产品名称：Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC
    产品型号：FCMAB282F
    Detect Integrin αVβ3 using this Milli-Mark Anti-Integrin αVβ3 Antibody, clone LM609-FITC validated for use in FC.

    merck millipore,默克密理博,FCMAB282F,Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC

  • 产品介绍
  • merck millipore,默克密理博,FCMAB282F,Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 FCMAB282F
    商名
    • Milli-Mark
    描述 Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC
    Alternate Names
    • alphaVbeta3
    • Vitronectin Receptor
    • CD51/CD61
    • integrin alphaVbeta3
    背景信息 The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The adhesion receptor, integrin alphaVbeta3, appears to be selectively expressed on growing blood vessels and has been identified as a marker of angiogenic vascular tissue (Brooks, 1994). Due to its involvement in angiogenesis, integrin alphaVbeta3 is one of the most intensely studied of the integrin receptors.
    产品信息
    格式 FITC
    控制
    • U937 cells
    演示 Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Detect Integrin αVβ3 using this Milli-Mark Anti-Integrin αVβ3 Antibody, clone LM609-FITC validated for use in FC.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Purified adhesion receptor from the human melanoma cell line M21 (Cherish, D. and Spiro, R. (1987) J. Biol. Chemistry, 262(36):17703-17711).
    克隆 LM609
    宿主 Mouse
    特异性 Antibody recognizes Integrin αVβ3.
    同种型 IgG1
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002201
    基因符号
    • VNRA
    • ITGAV
    • DKFZp686A08142
    • MSK8
    • CD51
    纯化方法 Protein A Purified
    UniProt编号
    • P06756
    UniProt汇总 FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

    SIZE: 1048 amino acids; 116038 Da

    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    质量保证 Evaluated by flow cytometry using U937 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Flow Cytometry
    Antibody dilution for cellular staining:

    • Prepare an antibody working solution by diluting the primary antibody 1:5 with PBS
    • Dispense the volume per test of working of solution according to the number of cells indicated in the table below.
    • 5 µL for Guava Flow Cytometer
    • 10 µL for other Flow Cytometry instruments
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB282F,Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC

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