- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Po, H, M, R IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-584 品牌系列 Upstate
商名 - Upstate
描述 Anti-Tie2/TEK Antibody, clone Ab33 Alternate Names - soluble TIE2 variant 2venous malformations, multiple cutaneous and mucosal
- CD202b antigen
- TEK tyrosine kinase, endothelial
- Tunica interna endothelial cell kinase
- Tyrosine-protein kinase receptor TEK
- Tyrosine-protein kinase receptor TIE-2
- p140 TEK
- soluble TIE2 variant 1
- soluble TIE2 variant 1
- soluble TIE2 variant 2venous malformations
背景信息 TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin-like loops separated by three epidermal growth factor-like repeats that are connected to three fibronectin type III-like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. 产品信息 格式 Purified 控制 - HUVEC cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide before the addition of glycerol to 30%. Liquid at -20°C. 应用 应用 This Anti-Tie2/TEK Antibody, clone Ab33 is validated for use in WB, IP, IH for the detection of Tie2/TEK. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunoprecipitation: This antibody immunoprecipitated Tie2/TEK, as reported by an independent laboratory.
Immunohistochemistry: Reported to detect Tie2/TEK in frozen, Triton-treated sections.
This antibody is not suitable for paraffin-embedded sections.生物信息 免疫原品种 Fusion protein corresponding to residues 1-745 of human Tie2/TEK with a C-terminal His6-tag purified from infected SF-9 cells. Clone Ab33 克隆 clone Ab33 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes Tie2/TEK, Mr 145kDa 同种型 IgG1κ 品种反应性 PigHumanMouseRat Species Reactivity Note Human, mouse, rat, and pig. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000459
Entrez基因汇总 The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. 基因符号 - TIE-2
- TEK
- CD202B
- TIE2
- VMCM1
- VMCM
- hTIE2
- CD202b
纯化方法 Protein G purfied UniProt编号 - Q02763
UniProt汇总 FUNCTION: SwissProt: Q02763 # This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
SIZE: 1124 amino acids; 125811 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
DISEASE:SwissProt: Q02763 # Defects in TEK are a cause of dominantly inherited venous malformations (VMCM) [MIM:600195]; an error of vascular morphogenesis characterized by dilated, serpiginous channels.
SIMILARITY: SwissProt: Q02763 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. & Contains 3 EGF-like domains. & Contains 3 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.产品使用声明 质量保证 Evaluated by western blot on RIPA lysates from HUVEC cells.
Western Blot Analysis: 0.2-1 μg/mL of this antibody detected Tie2/TEK in RIPA lysates from HUVEC cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at from date of receipt. 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,MABN369,Anti-Neuroglobin Antibody, clone 6G1.1
下一件merck millipore产品：merck millipore,默克密理博,475880,ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem
相关产品
merck millipore,默克密理博,FCMAB282F,Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC
merck millipore,默克密理博,71252,Veggie BL21(DE3) Singles™ Competent Cells - Novagen
merck millipore,默克密理博,ABE434,Anti-TIF1-alpha Antibody
merck millipore,默克密理博,05-1925,Anti-Lactoylglutathione lyase Antibody, clone Glo1a
merck millipore,默克密理博,MABN369,Anti-Neuroglobin Antibody, clone 6G1.1
merck millipore,默克密理博,475880,ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem
merck millipore,默克密理博,MAB1962Z,Anti-Integrin β2 Antibody, clone P4H9, azide free
merck millipore,默克密理博,AB15560-50UL,Anti-TRPM1 Antibody
merck millipore,默克密理博,444231,MMP-9, Monomer, Human Neutrophil
merck millipore,默克密理博,SF-1769,LAMP1; Human, Cyanine 5 RNA Detection Probe,SmartFlare