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描述 产品目录编号 AG217 品牌系列 Chemicon®
商名 - Chemicon
描述 Histamine Receptor 4, control peptide for AB5663P 概述 Synthetic 17 amino acid peptide sequence within the cytoplasmic, C-terminus of human HR4. 产品信息 演示 Liquid in PBS containing 0.1% sodium azide. 应用 主要应用 - Cell Function Assay
应用说明 For use in blocking the reactivity of AB5663P.
Optimal working dilution must be determined by the end user.生物信息 浓缩 1.0 mg/mL 品种 Human Entrez基因编号 - NM_021624.2
Entrez基因汇总 Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors. 基因符号 - BG26
- HRH4
- MGC133027
- GPCR105
- HH4R
- GPRv53
- H4R
- H4
- AXOR35
- SP9144
UniProt编号 - Q9H3N8
UniProt汇总 FUNCTION: SwissProt: Q9H3N8 # The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
SIZE: 390 amino acids; 44496 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, fetal liver and lymph node.
SIMILARITY: SwissProt: Q9H3N8 ## Belongs to the G-protein coupled receptor 1 family.
MISCELLANEOUS: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha- methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha- methylhistamine > R(-)-alpha-methylhistamine behave as full agonists.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles 包装信息 数量 100 µg
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