merck millipore,默克密理愽
  • merck millipore,默克密理博,204001,BX-795 - CAS 702675-74-9 - Calbiochem

  • merck millipore,默克密理博,204001,BX-795 - CAS 702675-74-9 - Calbiochem

    产品名称：BX-795 - CAS 702675-74-9 - Calbiochem
    产品型号：204001
    BX-795, also referenced under CAS 702675-74-9, modulates the biological activity of multiple kinases. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicatio More>>

    merck millipore,默克密理博,204001,BX-795 - CAS 702675-74-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,204001,BX-795 - CAS 702675-74-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₂₆IN₇O₂S702675-74-9
    描述
    概述 A cell-permeable aminopyrimidine compound that acts as a potent, ATP-competitive and reversible multi-kinase inhibitor (IC50 = 11 nM for PDK1 at ≤ 10 µM of ATP; IC50 = 5 , 6, 19, 31, 41 and 111 nM for NUAK1, TBK1, MARK4, Aurora B, IKKε and PDK1 at 100 µM of ATP, respectively) and displays 50-fold greater selectivity over Cdk2/E, EGFR, GSK-3β, IR, c-Kit, PKA, PKC, TAK1 and VEGFR. Shown to block PDK1/Akt signaling, induce growth arrest and apoptosis in PC-3 and MDA-468 cells (IC50 = 0.25 and 0.75 µM, respectively); further, inhibit phosphorylation (pSer396), nuclear translocation and transcriptional activity of IRF3 and reduce IFN-β production in stimulated macrophages.
    产品目录编号 204001
    品牌系列 Calbiochem®
    同义词 N-(3-((5-Iodo-4-((3-(2-thienylcarbonyl)amino)propyl)amino)-2-pyrimidinyl)amino)phenyl)-1-pyrrolidinecarboxamide, Aurora Kinase Inhibitor VIII, AMPK Related Kinase 5 Inhibitor I, ARK5 Inhibitor I, NUAK Kinase Inhibitor I, NUAK1 Inhibitor I, SnF1 Like Kinase-1 Inhibitor I
    参考
    参考 Clark, K., et al. 2009. J. Biol. Chem. 284, 14136.
    Tamgumcy, T., et al. 2008. Exp. Cell Res. 314, 2299.
    Feldman, R.I., et al. 2005. J. Biol. Chem. 280, 19867.
    产品信息
    CAS号 702675-74-9
    形式 Pale yellow solid
    Hill配方 C₂₃H₂₆IN₇O₂S
    化学配方 C₂₃H₂₆IN₇O₂S
    Molar Mass 591.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,204001,BX-795 - CAS 702675-74-9 - Calbiochem

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