merck millipore,默克密理愽
  • merck millipore,默克密理博,14-197M,Casein Kinase 2 Protein, active, 250 µg

  • merck millipore,默克密理博,14-197M,Casein Kinase 2 Protein, active, 250 µg

    产品名称：Casein Kinase 2 Protein, active, 250 µg
    产品型号：14-197M
    Active, recombinant full-length human Casein Kinase 2 protein, containing an α-subunit N-terminal 6His tag & a β-subunit N-terminal GST tag. For use in Kinase Assays.

    merck millipore,默克密理博,14-197M,Casein Kinase 2 Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-197M,Casein Kinase 2 Protein, active, 250 µg

    描述
    产品目录编号 14-197M
    品牌系列 Upstate
    商名
    • Upstate
    描述 Casein Kinase 2 Protein, active, 250 µg
    概述 Recombinant full-length human Casein Kinase 2 protein, containing an &alpyha;-subunit N-terminal 6His tag and a β-subunit N-terminal GST tag.
    产品信息
    演示 20mM MOPS, pH 7.4, 1mM EDTA, 0.1% (v/v) Triton X-100, 0.3% 2-mercaptoethanol, 1mM benzamidine, 50% glycerol.
    应用
    应用 Active, recombinant full-length human Casein Kinase 2 protein, containing an α-subunit N-terminal 6His tag & a β-subunit N-terminal GST tag. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed in Sf21 insect cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_177560.2
    • NM_001895.3
    • NM_177559.2
    Entrez基因汇总 Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
    基因符号
    • CKII
    • CSNK2A1
    • CK2A1
    蛋白靶 CK2
    纯化方法 Sequential chromatography using heparin Sepharose™ and Mono Q anion exchange resin
    靶子系列 CMGC
    UniProt编号
    • P68400
    UniProt汇总 FUNCTION: SwissProt: P68400 # Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.
    SIZE: 391 amino acids; 45144 Da
    SUBUNIT: Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with RNPS1.
    SIMILARITY: SwissProt: P68400 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of the Casein Kinase 2 Substrate Peptide.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C.
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-197) and in bulk (cat# 14-197-K).

    merck millipore,默克密理博,14-197M,Casein Kinase 2 Protein, active, 250 µg

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