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品种反应性 主要应用 宿主 格式 抗体类型 Ca, H, M, R, B ICC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT10 描述 Anti-CKAP5 Antibody Alternate Names - Ch-TOG
- Cytoskeleton-associated protein 5
- Colonic and hepatic tumor over-expressed gene protein
背景信息 Cytoskeleton-associated protein 5 (CKAP5) is a member of the TOG/XMAP215 family containing heat repeats and plays a role in kinetochore mircotubule protection from depolymerization by MCAK. CKAP5 is the homolog of the Xenopus protein, XMAP25 (also known as chTog), which plays an essential role in centrosomal assembly. CKAP5 is localized in the perinuclear cytoplasm during interphase and at the spindle poles and centrosomes during mitosis. Studies show CKAP5 interacts with TACC1, TACC3, and tubulin leading to the hypothesis that it functions in spindle microtuble organization. Hepatomas and colonic tumors have shown overexpression of CKAP5. 产品信息 格式 Affinity Purified 控制 - A431 cells
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-CKAP5 Antibody is an antibody against CKAP5 for use in IC. 主要应用 - Immunocytochemistry
应用说明 Immunocytochemistry Analysis: A 1:250 dilution from a previous lot detected CKAP5 in RPE1 cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human CKAP5. 宿主 Rabbit 品种反应性 CanineHumanMouseRatBovine Species Reactivity Note Demonstrated to react with Human.
Predicted to react with Mouse, Rat, Bovine, and Canine based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001008938
Entrez基因汇总 This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]. 基因符号 - CKAP5
纯化方法 Affinity Purified UniProt编号 - Q14008
UniProt汇总 FUNCTION: Plays a major role in organizing spindle poles.
SUBUNIT STRUCTURE: Interacts with TACC1.
TISSUE SPECIFICITY: Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas.
SEQUENCE SIMILARITIES: Belongs to the TOG/XMAP215 family.
Contains 10 HEAT repeats.
SEQUENCE CAUTION: The sequence AAH17856.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH70136.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAI11044.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAI20871.1 differs from that shown. Reason: Frameshift at position 18.
The sequence BAA07892.2 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Immunocytochemistry in A431 cells.
Immunocytochemistry Analysis: A 1:500 dilution of this antibody detected CKAP5 in A431 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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