merck millipore,默克密理愽
  • merck millipore,默克密理博,565840,SHIP2 Inhibitor, AS1938909 - Calbiochem

  • merck millipore,默克密理博,565840,SHIP2 Inhibitor, AS1938909 - Calbiochem

    产品名称：SHIP2 Inhibitor, AS1938909 - Calbiochem
    产品型号：565840
    The SHIP2 Inhibitor, AS1938909 controls the biological activity of SHIP2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,565840,SHIP2 Inhibitor, AS1938909 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,565840,SHIP2 Inhibitor, AS1938909 - Calbiochem

    重要规格表

    经验配方
    C₁₉H₁₃Cl₂F₂NO₂S
    描述
    概述 A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki = 0.44 µM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50 = 0.18, 0.57, 21, > 50, > 50 and > 50 µM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available (Cat. No. 565835).
    产品目录编号 565840
    品牌系列 Calbiochem®
    同义词 3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 domain-containing inositol 5ʹ-phosphatase 2 (SHIP2) Inhibitor, AS1938909
    参考
    参考 Suwa, A., et al. 2010. Eur. J. Pharmacol. 642, 177.
    Suwa, A., et al. 2009. Br. J. Pharmacol. 158, 879.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₉H₁₃Cl₂F₂NO₂S
    化学配方 C₁₉H₁₃Cl₂F₂NO₂S
    Molar Mass 428.3
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,565840,SHIP2 Inhibitor, AS1938909 - Calbiochem

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