merck millipore,默克密理博,04-1095,Anti-IL-6 Antibody, clone E457, rabbit monoclonal

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merck millipore,默克密理博,04-1095,Anti-IL-6 Antibody, clone E457, rabbit monoclonal
产品名称：Anti-IL-6 Antibody, clone E457, rabbit monoclonal
产品型号：04-1095
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect IL-6 using this Anti-IL-6 Antibody, clone E45 More>>

merck millipore,默克密理博,04-1095,Anti-IL-6 Antibody, clone E457, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1095,Anti-IL-6 Antibody, clone E457, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1095
描述	Anti-IL-6 Antibody, clone E457, rabbit monoclonal
Alternate Names	interleukin 6 (interferon, beta 2) B-cell stimulatory factor 2 CTL differentiation factor Hybridoma growth factor Interferon beta-2 interleukin 6
背景信息	Interleukin-6 (IL-6) is a potent lymphoid cell growth factor which affects B-lymphocytes, T-lymphocytes and hybridoma cells. It will also affect cytotoxic T-cells in combination with other factors such as IL-2 and g-interferon. Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

产品信息
格式	Unpurified
控制	Recombinant protein
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect IL-6 using this Anti-IL-6 Antibody, clone E457, Rabbit validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	Recombinant human IL-6 protein.
克隆	E457
宿主	Rabbit
特异性	This antibody recognizes IL-6.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_000591.1
基因符号	IL-6 BSF-2 BSF2 CDF HGF HSF IFNB2
纯化方法	Unpurified
UniProt编号	P05231
UniProt汇总	FUNCTION: IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants. SUBCELLULAR LOCATION: Secreted. PTM: N- and O-glycosylated. Ref.14 Polymorphism Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture. INVOLVEMENT IN DISEASE: Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. At least 1 polymorphism in the IL6 gene renders HIV-infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS. SEQUENCE SIMILARITIES: Belongs to the IL-6 superfamily.

产品使用声明
质量保证	Evaluated by Western Blotting on recombinant protein. Western Blotting Analysis: 1:10,000 dilution of this antibody detected IL-6 on recombinant protein.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.