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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-414 品牌系列 Upstate
商名 - Upstate
描述 Anti-CrkL Antibody, clone 5-6 背景信息 CRKL is a 39kDa adaptor protein with one SH2 and two SH3 binding domains. CRKL is the major protein which is tyrosine phosphorylated in response to BCR/ABL (chronic myelogenous leukemia) and growth factor activation. In myeloid cells, it binds to proteins such as paxillin, p130cas and p120 cbl. CRKL aslo appears to bind ABL and SOS.
The antibody does not cross-react with CRKI or CRKII.
产品信息 格式 Purified 控制 - Western Blot and Immunoprecipitation:
K562 cell lysate
Immunocytochemistry:
Hela cells
演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. 应用 应用 Detect CrkL using this Anti-CrkL Antibody, clone 5-6 validated for use in IP, WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Full length GST fusion protein corresponding to Human CRKL 表位 Full-length 克隆 5-6 宿主 Mouse 特异性 the C-terminal SH3 of Human CRKL 同种型 IgG2aκ 品种反应性 RatHumanMouse Species Reactivity Note Reacts with human, mouse and rat. Other species have not been tested. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005207
Entrez基因汇总 v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. 基因符号 - CRKL
纯化方法 Protein G purfied UniProt编号 - P46109
UniProt汇总 FUNCTION: SwissProt: P46109 # May mediate the transduction of intracellular signals.
SIZE: 303 amino acids; 33777 Da
SUBUNIT: Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB.
SIMILARITY: SwissProt: P46109 ## Contains 1 SH2 domain. & Contains 2 SH3 domains.产品使用声明 质量保证 Routinely evaluated by Western Blot on K562 cell lysate.
Western Blot Analysis: Antibody detected CRKL in 15 μg of K562 cell lysate.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. 包装信息 数量 100 µg
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