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merck millipore,默克密理博,FCMAB289A4,Milli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49
产品名称：Milli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49
产品型号：FCMAB289A4
Milli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 is an antibody against PINK1-Alexa Fluor 488 for use in FC.
merck millipore,默克密理博,FCMAB289A4,Milli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 FCMAB289A4 商名 - Milli-Mark
描述 Milli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 Alternate Names - Parkinson disease (autosomal recessive) 6
- PTEN induced putative kinase 1
- protein kinase BRPK
- serine/threonine-protein kinase PINK1
- PTEN-induced putative kinase protein 1
背景信息 Mutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. 产品信息 格式 AlexaFluor®488 控制 - HEK293 cells
演示 Purified mouse monoclonal IgG1k conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 is an antibody against PINK1-Alexa Fluor 488 for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Recombinant protein corresponding to human PINK1. 克隆 N4/49 宿主 Mouse 特异性 Antibody recognizes human PINK1. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Tested and passed on Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_115785
Entrez基因汇总 This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. 基因符号 - BRPK
- PINK1
- PARK6
纯化方法 Protein G Purified UniProt编号 - Q9BXM7
UniProt汇总 FUNCTION: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
PTM: Autophosphorylated.
INVOLVEMENT IN DISEASE: Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 protein kinase domain.产品使用声明 质量保证 Evaluated by flow cytometry using HEK293 cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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