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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS68 描述 Anti-Fer Antibody Alternate Names - p94-Fer
- Tyrosine-protein kinase Fer
- Proto-oncogene c-Fer
- Tyrosine kinase 3
背景信息 FER tyrosine kinase is involved in cadherin, PECAM-1, and integrin mediated cytoskeletal connections. More recent research has also linked FER to decreasing the innate immune response. FER has also been implicated in the control of lipopolysaccharide induced epithelial dysfunction. FER has been shown to be essential in microtubule characteristics in the oocyte meiotic spindle and could also play a role in germinal vesicle breakdown. 产品信息 格式 Affinity Purified 控制 - HEK293 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Fer using this Anti-Fer Antibody validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 1:500 dilution of a representative lot of this antibody detected Fer in lymphoid cells within the germinal centers and outside the mantle zone of normal human tonsil tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Fer. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005237
Entrez基因汇总 Summary: Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq]. 基因符号 - TYK3
- FER
纯化方法 Affinity purified UniProt编号 - P16591
UniProt汇总 FUNCTION: Tyrosine kinase of the non-receptor type. Probably performs an important function, perhaps in regulatory processes such as cell cycle control.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Associated with the chromatin.
TISSUE SPECIFICITY: Expressed in a variety of lymphoid cell lines.
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Contains 1 FCH domain. Contains 1 protein kinase domain. Contains 1 SH2 domain.产品使用声明 质量保证 Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Fer on 10 µg of HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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