merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2254,Anti-Tropomyosin Antibody, clone 15D12.2

  • merck millipore,默克密理博,MAB2254,Anti-Tropomyosin Antibody, clone 15D12.2

    产品名称：Anti-Tropomyosin Antibody, clone 15D12.2
    产品型号：MAB2254
    Detect Tropomyosin using this Anti-Tropomyosin Antibody, clone 15D12.2 validated for use in WB, IH.

    merck millipore,默克密理博,MAB2254,Anti-Tropomyosin Antibody, clone 15D12.2

  • 产品介绍
  • merck millipore,默克密理博,MAB2254,Anti-Tropomyosin Antibody, clone 15D12.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, M, HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2254
    描述 Anti-Tropomyosin Antibody, clone 15D12.2
    Alternate Names
    • alpha tropomyosin
    • tropomyosin 1 (alpha)
    • cardiomyopathy, hypertrophic 3
    • tropomyosin 1 alpha chain
    • HTM-alpha
    • Alpha-tropomyosin
    • chromosome 15 open reading frame 13
    • Tropomyosin-1
    • sarcomeric tropomyosin kappa
    背景信息 Tropomyosins (Tms) are a family of >40 highly conserved protein isoforms resulting from alternative splicing of four different genes during development and that are expressed in numerous cell types. These proteins form coiled-coil heterodimers which bind to actin polymers along the α-helical grove. Tropomyosin’s function varies depending on cell type in which it is expressed. Within muscle, Tms play a role in the regulation of actin-myosin interplay for the purpose of mediating muscle contraction. In non-muscle cells, studies suggest a role in the stabilization of actin filaments, along with protecting actin filaments from the severing action of gelsolin and ADF/cofilin depolymerization. Tms also appear to have a role in the moderation of access to actin for other actin-binding proteins. Tropomyosin has an integral role in maintaining cardiovascular homeostasis. Down-regulation of Tms expression has been observed in tumor cells indicating a possible role for Tms as tumor suppressors.
    产品信息
    格式 Purified
    控制
    • Mouse brain tissue lysate
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Tropomyosin using this Anti-Tropomyosin Antibody, clone 15D12.2 validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: 1:300 dilution from a representative lot detected Tropomyosin in human striated muscle tissue.
    生物信息
    免疫原品种 Linear peptide corresponding to the entire exon 9d of rat Tropomyosin.
    表位 Exon 9d
    克隆 15D12.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 The antibody recognizes the entire exon 9d of Tropomyosin.
    同种型 IgG2bκ
    品种反应性 RatMouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse. Predicted to react with rat based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001029243
    Entrez基因汇总 This gene is a member of the tropomyosin family and encodes a protein that heterodimerizes with a beta subunit, binding actin in both muscle and nonmuscle cells. In both smooth and striated muscle cells, it plays a role in calcium dependent-regulation of muscle contraction. In nonmuscle cells, it stabilizes cytoskeleton actin filaments. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
    基因符号
    • CMH3
    • TPM1
    • TMSA
    • C15orf13
    • CMD1Y
    纯化方法 Protein G
    UniProt编号
    • Q923Z2
    UniProt汇总 SEQUENCE SIMILARITIES: Belongs to the tropomyosin family.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse brain tissue lysate.

    Western Blot Analysis: 0.5 µg/mL of the antibody detected Tropomyosin in 10 µg of mouse brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2254,Anti-Tropomyosin Antibody, clone 15D12.2

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下一件merck millipore产品：merck millipore,默克密理博,MAB3422,Anti-Histone Antibody, clone H11-4


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