merck millipore,默克密理愽
  • merck millipore,默克密理博,648492,TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem

  • merck millipore,默克密理博,648492,TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem

    产品名称：TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem
    产品型号：648492
    The TRPM4 inhibitor, 9-Phenanthrol, also referenced under CAS 484-17-3, controls the biological activity of TRPM4. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,648492,TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,648492,TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₁₀O484-17-3
    描述
    概述 A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
    产品目录编号 648492
    品牌系列 Calbiochem®
    同义词 Phenanthren-9-ol, 9-Hydroxyphenanthrene
    参考
    参考 Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
    Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
    产品信息
    CAS号 484-17-3
    形式 Brown solid
    Hill配方 C₁₄H₁₀O
    化学配方 C₁₄H₁₀O
    Molar Mass 194.2
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,648492,TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem

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