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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-696 品牌系列 Upstate
商名 - Upstate
描述 Anti-Flt-1 Antibody, clone BK302 产品信息 格式 Purified 演示 of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect Flt-1 using this Anti-Flt-1 Antibody, clone BK302 validated for use in WB. 主要应用 - Western Blotting
应用说明 Not recommended for IP. 生物信息 免疫原品种 GST fusion protein corresponding to residues 1251-1338 of human Flt-1 克隆 BK302 宿主 Mouse 特异性 Flt-1 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002019
Entrez基因汇总 Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM] 基因符号 - Flt-1
- FLT1
- VEGFR1
- FLT
- FRT
- VEGFR-1
纯化方法 Protein G purfied UniProt编号 - P17948
UniProt汇总 FUNCTION: SwissProt: P17948 # Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
SIZE: 1338 amino acids; 150769 Da
SUBUNIT: Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1.
SUBCELLULAR LOCATION: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. & Isoform sFlt1: Secreted.
TISSUE SPECIFICITY: Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.
SIMILARITY: SwissProt: P17948 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoblot on Human umbilical vein endothelium (HUVEC) membrane preps 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,648492,TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,07-306,Anti-CtBP-1 Antibody
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