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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-306 品牌系列 Upstate
商名 - Upstate
描述 Anti-CtBP-1 Antibody 背景信息 The phosphoprotein C-terminal binding protein 1 (CtBP1) binds the C-terminus of adenovirus E1A protein. CtBP1 is a transcriptional repressor and may play a role during cellular proliferation. 产品信息 格式 Purified 控制 - HeLa nuclear extract
演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-CtBP-1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of CtBP-1 & has been validated in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 425-440 (QTVKPEADRDHASDQL) of human CtBP-1 宿主 Rabbit 特异性 CtBP-1 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001328
Entrez基因汇总 This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. 基因符号 - CTBP
- CTBP1
- CtBP1
- BARS
- MGC104684
纯化方法 Protein A chromatography UniProt编号 - Q13363
UniProt汇总 FUNCTION: SwissProt: Q13363 # Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co- repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity.
COFACTOR: NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change.
SIZE: 440 amino acids; 47535 Da
SUBUNIT: Interacts with the C-terminus of adenovirus E1A protein, ELK3 and CTIP via their consensus motif P-X-[DNS]-L-[STVA]. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with FOXP2, HDAC4, HDAC5 and HDAC9. Interacts with GLIS2 but not GLIS1 or GLIS3 (By similarity). Interacts with FOXP1, HIPK2, PNN and NRIP1. Interacts with ZFHX1B and WIZ.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
PTM: The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation. & ADP-ribosylated; when cells are exposed to brefeldin-A (BFA) (By similarity). & Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.
SIMILARITY: SwissProt: Q13363 ## Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.产品使用声明 质量保证 routinely evaluated by immunoblot on nuclear extract from HeLa cells, as well as in RIPA lysates from 3T3/A31, A431 or Jurkat cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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下一件merck millipore产品：merck millipore,默克密理博,14-1051,Human recombinant H3.3 core histone octamers
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