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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS205 描述 Anti-STK33 Antibody Alternate Names - Serine/threonine-protein kinase 33
背景信息 STK33 is a serine/threonine protein kinase that promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through S6K1-induced inactivation of BAD. It is selectively required for the survival and proliferation of mutant KRAS-dependent cancer cells across a wide range of tissue contexts. STK33 is expressed in low amounts in most tissues; however, it is highly expressed in testis, particularly in cells from the spermatogenic epithelia. Moreover, significant expression is found in alveolar macrophages, lung epithelia, horizontal cells in the retina, and in embryonic organs such as brain, heart, and spinal cord. STK33 is suggested to play a role in spermatogenesis and organ ontogenesis. 产品信息 格式 Affinity Purified 控制 - Human heart tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect STK33 using this Anti-STK33 Antibody validated for use in Western Blotting, Multiplexing, IHC(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry (Paraffin) Analysis: A previous lot of this antibody was used to detect STK33 in the seminiferous tubule epethelium of rat testis.
Multiplex Assay: A previous lot of this antibody was used in Multiplex Assays.生物信息 免疫原品种 Histidine-tagged recombinant protein corresponding to human STK33. 宿主 Rabbit 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_112168
基因符号 - STK33
纯化方法 Affinity Purified UniProt编号 - Q9BYT3
UniProt汇总 CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Cytoplasm > perinuclear region.
TISSUE SPECIFICITY: Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system.产品使用声明 质量保证 Evaluated by Western Blot in human heart tissue lysate.
Western Blot Analysis: A 1:250 dilution of this antibody detected STK33 in 10 µg of human heart tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µL
上一件merck millipore产品：merck millipore,默克密理博,400036,Glucose Transporter Inhibitor IV, WZB117 - CAS 1223397-11-2 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,475825,mitoNEET Inhibitor NL-1, Thiazolidinedione - Calbiochem
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