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merck millipore,默克密理博,400036,Glucose Transporter Inhibitor IV, WZB117 - CAS 1223397-11-2 - Calbiochem
产品名称：Glucose Transporter Inhibitor IV, WZB117 - CAS 1223397-11-2 - Calbiochem
产品型号：400036
The Glucose Transporter Inhibitor IV, WZB117 controls the biological activity of Glucose Transporter.
merck millipore,默克密理博,400036,Glucose Transporter Inhibitor IV, WZB117 - CAS 1223397-11-2 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,400036,Glucose Transporter Inhibitor IV, WZB117 - CAS 1223397-11-2 - Calbiochem
重要规格表
经验配方 CAS号 C₂₀H₁₃FO₆ 1223397-11-2 描述 概述 A bis-hydroxybenzoate compound that acts as a fast-acting, irreversible blocker of glucose transport by GLUT1 in red blood cells. Shown to rapidly inhibit glucose transport in cancer cells (IC50 ~ 500 nM in A549 cells) and block proliferation. Its inhibitory effects are more pronounced in hypoxic cancer cells. It binds directly to GLUT1 involving three hydrogen bonds, one each with Asn34, Arg126, and Trp412. Also shown to reduce the levels of GLUT1 protein, intracellular ATP levels, and glycolytic enzymes and increase the level of AMPK in tumor cells. Preferentially induces cell cycle arrest and causes senescence and necrosis in red blood cells and tumor cells (IC50 = 10 µM) over non cancerous cells and synergizes the anti-tumor effects of cisplatin (Cat. No. 232120) and paclitaxel (Cat. No. 580555). Also, effectively suppresses tumor growth in human A549 lung cancer grafted nude mice model (10 mg/kg, i.p., daily). 产品目录编号 400036 品牌系列 Calbiochem®
同义词 GLUT Inhibitor IV, WZB117, 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate) 参考 参考 Liu. Y., et al. 2012. Mol. Cancer Ther. 11, 1672. 产品信息 CAS号 1223397-11-2 形式 White powder Hill配方 C₂₀H₁₃FO₆ Molar Mass 368.3 可逆 N 结构配方图像 生物信息 主靶 Glut1 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
防潮 Protect from moisture
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Unstable in DMSO. 包装信息 惰性气体下包装 Packaged under inert gas
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