merck millipore,默克密理愽
  • merck millipore,默克密理博,557514,Ro-31-8425 - CAS 131848-97-0 - Calbiochem

  • merck millipore,默克密理博,557514,Ro-31-8425 - CAS 131848-97-0 - Calbiochem

    产品名称：Ro-31-8425 - CAS 131848-97-0 - Calbiochem
    产品型号：557514
    A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC₅₀ = 15 nM for rat brain PKC).

    merck millipore,默克密理博,557514,Ro-31-8425 - CAS 131848-97-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,557514,Ro-31-8425 - CAS 131848-97-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₆H₂₄N₄O₂ · HCl131848-97-0
    描述
    概述 A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε). Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
    产品目录编号 557514
    品牌系列 Calbiochem®
    同义词 2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
    参考
    参考 Levy, O., et al. 2015. Cell Reports 10, In press.
    Merritt, J.E., et al. 1997. Cell Signal 9, 53.
    Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
    产品信息
    CAS号 131848-97-0
    具有ATP竞争性 Y
    形式 Reddish-orange solid
    Hill配方 C₂₆H₂₄N₄O₂ · HCl
    化学配方 C₂₆H₂₄N₄O₂ · HCl
    Molar Mass 461.0
    可逆 Y
    结构配方图像
    生物信息
    主靶 PKC
    主靶IC50 15 nM for rat brain PKC; 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε
    纯度 ≥94% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,557514,Ro-31-8425 - CAS 131848-97-0 - Calbiochem

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